Results 111 to 120 of about 12,421,662 (339)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Assessing multiple score functions in Rosetta for drug discovery.

PLoS ONE, 2020
Rosetta is a computational software suite containing algorithms for a wide variety of macromolecular structure prediction and design tasks including small molecule protocols commonly used in drug discovery or enzyme design.
Shannon T Smith, Jens Meiler
doaj   +1 more source

Ranking Inequality: Applications of Multivariate Subset Selection [PDF]

Inequality measures are often presented in the form of a rank ordering to highlight their relative magnitudes. However, a rank ordering may produce misleading inference, because the inequality measures themselves are statistical estimators with different
William C. Horrace, Joseph T. Marchand, Timothy M. Smeeding   +2 more
core  

Learning ranking functions by genetic programming revisited

, 2018
Learning Ranking Functions by Genetic Programming ...
Lo Bianco, Giovanni, Baeza-Yates, Ricardo, Giovanni Lo Bianco, Domenico Crea, Alfredo Cuzzocrea, Cuzzocrea, Alfredo, Ricardo Baeza-Yates, Crea, Domenico   +7 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Value and ambiguity index based ranking method of single-valued trapezoidal neutrosophic numbers and its application to multi-attribute decision making [PDF]

Neutrosophic Sets and Systems, 2016
The objective of the paper ARE to introduce single-valued trapezoidal neutrosophic numbers(SVTrNNs), which is a special case of single-valued neutrosophic numbers and to develop a ranking method for ranking SVTrNNs.
Pranab Biswas , Surapati Pramanik, Bibhas C. Giri   +2 more
doaj  

Complete Ranking of Intuitionistic Fuzzy Numbers

Fuzzy Information and Engineering, 2016
Fuzzy number was introduced by Dubois and Prade [10] to handle imprecise numerical quantities. Later it was generalized to intuitionistic fuzzy number by Burillo et al. [5].
V. Lakshmana Gomathi Nayagam, S. Jeevaraj, Geetha Sivaraman   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A complete ranking principle for trapezoidal Hesitant fuzzy sets and its application in solving trapezoidal Hesitant fuzzy linear programming problems

Complex & Intelligent Systems
Decision-making is significant in economics, education, management, industries, and many real-life situations. Every decision-making problem does not have crisp parameters and restrictions, and may have uncertainties and qualitative information ...
Rakhi Bihari, S. Jeevaraj, Dragan Pamucar   +2 more
doaj   +1 more source