Results 41 to 50 of about 44,386 (235)
Characterization of Recovered Bitumen from Coarse and Fine Reclaimed Asphalt Pavement Particles
Infrastructures, 2019 In the current era of road construction, it is common to add a small amount of reclaimed asphalt pavement (RAP) in asphalt mixes without significantly changing properties such as stiffness and low-temperature cracking resistance. Not only can these mixes
Saeed S. Saliani +3 more
doaj +1 more source
Lectio Socialis, 2021 Son zamanlarda Türkçe rap müziğin dinleyici kitlesi hızla büyümekte ve bir popüler kültür ürünü olarak rap müzik ürettiği ve sunduğu değerlerle dikkat çekmektedir. Her ne kadar rap müzik alt kültür öğeleri taşıyan muhalif bir müzik türü olarak bilinse de
Hayriye Eylül Akdemi̇r, Esra Köten
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
AN EFFECTIVE CORPORATE CULTURE AS A NECESSARY CONDITION FOR STRATEGIC STABILITY
Модернизация, инновация, развитие, 2016 During global economic crisis, conflict situations at Russian enterprises should be overcome by improving the corporate culture. Corporate culture helps companies to adapt to changing external and internal business environment.
K. I. Kochetkova, I. O. Korchagina
doaj
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Applied Sciences, 2018 Recycled asphalt mixtures (RAM), which are prepared by blending reclaimed asphalt pavement (RAP), virgin bitumen and mineral additives, provide a variety of advantages, including resource recycling, reductions in costs, and reduced negative environmental
Zhen Yang +5 more
doaj +1 more source
Rapping about Mechanotransduction [PDF]
Developmental Cell, 2018 Mechanical cues can regulate cell proliferation and differentiation through the Hippo-YAP signaling network. Reporting in Nature, Meng et al. (2018) show that the Ras-related GTPase RAP2 connects extracellular matrix stiffness to Hippo pathway regulation, adding to our understanding of how mechanical cues are converted into changes in YAP activity.
Consuelo, Ibar, Kenneth D, Irvine
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source