Results 61 to 70 of about 86,732 (284)

AN EFFECTIVE CORPORATE CULTURE AS A NECESSARY CONDITION FOR STRATEGIC STABILITY

open access: yesМодернизация, инновация, развитие, 2016
During global economic crisis, conflict situations at Russian enterprises should be overcome by improving the corporate culture. Corporate culture helps companies to adapt to changing external and internal business environment.
K. I. Kochetkova, I. O. Korchagina
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Quantitative Analysis of the Blending Degree of Virgin and RAP Binders in Recycled Asphalt Mixtures with a High RAP Content

open access: yesApplied Sciences, 2018
Recycled asphalt mixtures (RAM), which are prepared by blending reclaimed asphalt pavement (RAP), virgin bitumen and mineral additives, provide a variety of advantages, including resource recycling, reductions in costs, and reduced negative environmental
Zhen Yang   +5 more
doaj   +1 more source

Rapping about Mechanotransduction [PDF]

open access: yesDevelopmental Cell, 2018
Mechanical cues can regulate cell proliferation and differentiation through the Hippo-YAP signaling network. Reporting in Nature, Meng et al. (2018) show that the Ras-related GTPase RAP2 connects extracellular matrix stiffness to Hippo pathway regulation, adding to our understanding of how mechanical cues are converted into changes in YAP activity.
Consuelo, Ibar, Kenneth D, Irvine
openaire   +2 more sources

Initial experience with a novel resection and plication (RAP) method for acid reflux: a pilot study

open access: yesEndoscopy International Open, 2018
Background and study aims Current endoscopic therapies for gastroesophageal reflux disorder (GERD) are limited by technical complexity, and/or cost.
P. Benias   +7 more
semanticscholar   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Experimental Investigation of PCC Incorporating RAP

open access: yes, 2018
Rehabilitation and repair of flexible pavements produce huge amounts of reclaimed asphalt pavement (RAP) material. Using RAP in the formulation of portland cement concrete (PCC) is a technique that is part of a sustainable development approach since it ...
Sawssen El Euch Ben Said   +2 more
semanticscholar   +1 more source

A Sustainability Perspective for Unbound Reclaimed Asphalt Pavement (RAP) as a Pavement Base Material

open access: yesSustainability, 2018
The present study aims to investigate reclaimed asphalt pavement (RAP) materials for utilization for a pavement base layer material with the goal towards increasing the reutilization of materials and the movement towards increased pavement sustainability.
C. Plati, B. Cliatt
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Low Temperature Performance Characteristics of Reclaimed Asphalt Pavement (RAP) Mortars with Virgin and Aged Soft Binders

open access: yesApplied Sciences, 2017
Reclaimed asphalt pavement (RAP) has many advantages and is utilized to improve the high temperature properties of asphalt mixtures. Low temperature cracking is a predominant distress in asphalt pavements containing RAP materials. Thus, the evaluation of
Feipeng Xiao   +3 more
doaj   +1 more source

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