Results 141 to 150 of about 27,135,528 (306)

Valuing adaptation under rapid change [PDF]

, 2013
The methods used to plan adaptation to climate change have been heavily influenced by scientific narratives of gradual change and economic narratives of marginal adjustments to that change.
Celeste Young, John Handmer, Roger N Jones   +2 more
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Slope at Pactola Dam Construction Site, Silver City, Pennington County

, 1956
4 x 5 photograph, construction vehicles parked at the base of a tall hill, part of the hill has been shaped in preparation for the damMiscellaneous Subject File Black Hills Accommodations, Caves, Harney Peak, Lakes P77 Tab Lakes Black Hills Poster board
Rapid City Journal
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Rapid Transit Photographs -- Box 14, Folder 44 (February 26, 1921 - March 3, 1921) -- negative, 1921-03-01

, 2013
Photographer's notes written on negative: March 1, 1921 / Map of Cincinnati shows rapid transit look & interurbans ...
Unknown photographer, Cincinnati (Ohio). Interurban Rapid Transit Commission   +1 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Evaluation of a notes-based rapid qualitative analysis method to facilitate implementation

Implementation Science Communications
Background Qualitative methodologies offer a nuanced approach to understanding stakeholder perspectives, preferences, and context in implementation research.
Rachel Brown, Sofia Cigarroa Kennedy, Elena Carranco Chávez, Jeriel Dumeng-Rodriguez, Danielle Cullen   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Toward Analysis at the Point of Need: A Digital Microfluidic Approach to Processing Multi‐Source Sexual Assault Samples

Advanced Science
Forensic case samples collected in sexual assaults typically contain DNA from multiple sources, which complicates short‐tandem repeat (STR) profiling. These samples are typically sent to a laboratory to separate the DNA from sperm and non‐sperm sources ...
Mohamed Elsayed, Leticia Bodo, Christine Gaoiran, Palig Keuhnelian, Advikaa Dosajh, Vivienne Luk, Melissa Schwandt, Julie L. French, Alpana Ghosh, Barbara Erickson, Amanda G. Charlesworth, Jonathan Millman, Aaron R. Wheeler   +12 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Pactola Dam Construction Site, Silver City, Pennington County

, 1957
4 x 5 photograph, dirt and gravel road leading to a body of water, tree-covered hills are in the distanceMiscellaneous Subject File Black Hills Accommodations, Caves, Harney Peak, Lakes P77 Tab Lakes Black Hills Poster board Pactola Dam P77 [stamp ...
Rapid City Journal
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