Results 151 to 160 of about 27,135,528 (306)
Bury the ‘Irish Giant’: a rapid response to some positive rapid responses [PDF]
, 2012 Doyal, Len and Thomas L Muinzer, ‘Bury the “Irish Giant”: a rapid response to some positive rapid responses’ 1 February 2012, http://www.bmj.com/rapid-response/2012/02/01/re-should-skeleton-%E2%80%9C-irish-giant%E2%80%9D-be-buried-seaPeer ...
Doyal, Len, Muinzer, Thomas
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Water at Pactola Dam Construction Site, Silver City, Pennington County
, 1956 4 x 5 photograph, construction vehicles by a body of water, a dug-up area and a hill with some trees on it are in the backgroundMiscellaneous Subject File Black Hills Accommodations, Caves, Harney Peak, Lakes P77 Tab Lakes Black Hills Poster board ...
Rapid City Journal
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Program for Integration and Rapid Analysis of Mass Isotopomer Distributions (PIRAMID). [PDF]
Bioinformatics, 2023 Gomez JD +7 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Rapid Analysis of Phytic Acid by Paper Spray Mass Spectrometry. [PDF]
MoleculesGuo P, Zhu S, Chen B.
europepmc +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source