Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Rapid Analysis of Sports Prohibited Substances in Black Market Pharmaceutical Products Using Atmospheric Solids Analysis Probe-Mass Spectrometry. [PDF]
Henderson A +7 more
europepmc +1 more source
Chemometrics-assisted spectroscopic methods for rapid analysis of combined anti-malarial tablets. [PDF]
Pruksapha P +5 more
europepmc +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Implementing a rapid analysis framework to evaluate wellness initiatives in Massachusetts federally qualified health centers. [PDF]
Miranda I +10 more
europepmc +1 more source
Advancing Mycotoxin Detection: Multivariate Rapid Analysis on Corn Using Surface Enhanced Raman Spectroscopy (SERS). [PDF]
Gabbitas A, Ahlborn G, Allen K, Pang S.
europepmc +1 more source
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Immunofluorescence Rapid Analysis of Bisphenol A in Water Based on Magnetic Particles and Quantum Dots. [PDF]
Taranova NA +3 more
europepmc +1 more source
CRUSTY: a versatile web platform for the rapid analysis and visualization of high-dimensional flow cytometry data. [PDF]
Puccio S +9 more
europepmc +1 more source

