Results 131 to 140 of about 785,938 (310)

Systematic Review of Rapid Typhoid Diagnostic Kits

Journal of the Scientific Society
Typhoid fever is a bacterial infection that can be fatal and a major concern globally. Due to the infection’s high morbidity and fatality rates, there is an urgent need for precise and quick diagnostic tests to help with disease management and prevention.
Kanthishree B. Haritsa, P. Sangeetha
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

SARS-CoV-2 rapid antigen testing positive rate in community testing stations as an indicator for COVID-19 epidemic trend, Taipei, Taiwan, May to August 2021

Journal of the Formosan Medical Association
Background: Real-time surveillance of COVID-19 in large-scale community outbreaks presents challenges. Simple counts of the daily confirmed cases can be misleading due to constraints from bottlenecks in access to care or laboratory testing.
Kuang-Yu Niu, Yu-Chen Cheng, Cheng‐Wei Chan, Chung-Hsien Chaou, Chieh-Ching Yen, Chi-Tai Fang   +5 more
doaj   +1 more source

Assessment of the prozone effect in malaria rapid diagnostic tests [PDF]

BACKGROUND: The prozone effect (or high doses-hook phenomenon) consists of false-negative or false-low results in immunological tests, due to an excess of either antigens or antibodies.
Philippe Gillet, Marcella Mori, Marjan Van Esbroeck, Jef Van den Ende, Jan Jacobs, A Marx, D Bell, C Drakeley, World Health Organization, J Baker, GA Farcas, MP Grobusch, M Hawkes, P Pieroni, L Risch, M Heidelberger, JR Forney, L Risch, M Van der Palen, AH Moody, World Health Organization, PL Chiodini, M Mayxay, W Rennie, D Chilton, L Wiese, LK Erdman, World Health Organization, O Gaye, A Humar, NM Huong, T Jelinek, DJ Kyabayinze, C Ohrt, NW Stow, C Wongsrichanalai, MH Craig, T Jelinek, CK Murray, RW Peeling, M Trachsler, SA Harvey, ML McMorrow, D Moonasar, The Global Fund to Fight AIDS, Tuberculosis and Malaria   +44 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Laboratory evaluation of oral fluid for syphilis screening among clinic users from Lima, Peru

Microbiology Spectrum
Serological tests for syphilis require equipment unavailable in many health centers; however, point-of-care testing facilitates rapid screening using finger-prick whole blood samples. A further improvement could be oral fluid for ease of use.
Jazmin Qquellon, Silver K. Vargas, Francesca Vasquez, E. Michael Reyes-Diaz, Kelika A. Konda, Carlos F. Caceres, Jeffrey D. Klausner   +6 more
doaj   +1 more source

Specific immunoassays confirm association of Mycobacterium avium subsp. paratuberculosis with type-1 but not type-2 diabetes mellitus [PDF]

, 2009
Background Mycobacterium avium subspecies paratuberculosis (MAP) is a versatile pathogen with a broad host range. Its association with type-1 diabetes mellitus (T1DM) has been recently proposed.
Ahmed, Niyaz, Fadda, Giovanni, Gerlach, Gerald, Hasnain, Seyed E., Paccagnini, Daniela, Rosu, Valentina, Sechi, Leonardo Antonio, Zanetti, Stefania Anna Lucia   +7 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source