Results 1 to 10 of about 36,635 (234)

Standards for practical intravenous rapid drug desensitization & delabeling: A WAO committee statement. [PDF]

World Allergy Organ J, 2022
Las reacciones de hipersensibilidad a los medicamentos (DHR) a los medicamentos intravenosos pueden ser graves y pueden dejar a los pacientes y médicos en una posición difícil donde se debe suspender un tratamiento o intervención esencial. Incluso si prácticamente cualquier medicamento intravenoso puede desencadenar una DHR potencialmente mortal, los ...
Alvarez-Cuesta E, Madrigal-Burgaleta R, Broyles AD, Cuesta-Herranz J, Guzman-Melendez MA, Maciag MC, Phillips EJ, Trubiano JA, Wong JT, Ansotegui I, Steering Committee Authors, Review Panel Members.   +11 more
europepmc   +9 more sources

Use of Rapid Drug Desensitization in Delayed Hypersensitivity Reactions to Chemotherapy and Monoclonal Antibodies. [PDF]

Front Allergy, 2021
Background:Rapid drug desensitization (RDD) allows first-line therapies in patients with immediate drug hypersensitivity reactions (DHR) to chemotherapeutic drugs (ChD) and monoclonal antibodies (mAb). Desensitization in delayed drug reactions has traditionally used slow protocols extending up to several weeks; RDD protocols have been scarcely reported.
Vega A, Peña MI, Torrado I.
europepmc   +5 more sources

Implementation of Rapid Drug Desensitization in Antineoplastic Drug Therapy in Denmark Using One-Bag Protocols. [PDF]

Clin Transl Allergy
ABSTRACTBackgroundRapid drug desensitization (RDD) is the cornerstone of managing patients with immediate drug hypersensitivity reactions (IDHR) to antineoplastic drugs in Southern Europe and the United States. As the first in Northern Europe, an allergy treatment program that includes RDD and drug provocation testing (DPT) was implemented for Danish ...
Rasmussen TH, Mortz CG, Pfeiffer P, Andersen N, Mawn DG, Tannert LK, Basu MN, Rasmussen HM, Bindslev-Jensen C.   +8 more
europepmc   +4 more sources

Retrospective analysis of rapid drug desensitization with biologic agents: A single center experience. [PDF]

Clin Transl Allergy
AbstractBackgroundFollowing the increased use of biological agents, a subset of patients experiences hypersensitivity reaction (HSR). We reported our experience with rapid drug desensitization (RDD) to nine biologics (rituximab, infliximab, cetuximab, trastuzumab, pertuzumab, nivolumab, brentuximab, tocilizumab and filgrastim) and identified risk ...
Unutmaz Erkaya DG, Bayrak Durmaz MS, Görgülü Akın B, Bavbek S.   +3 more
europepmc   +4 more sources

A Failure of Rapid Drug Desensitization [PDF]

Military Medicine, 2021
ABSTRACT We present the case of a patient who was unable to tolerate rapid drug desensitization protocol to receive a continuous penicillin (PCN) G infusion for the treatment of neurosyphilis. A 38-year-old male with past medical history for human immunodeficiency virus, migraines, PCN allergy, doxycycline allergy, shellfish allergy, and
Benjamin S, Prewitt, Jun C, Mendoza, Christopher A, Coop, Samuel, Weiss, James M, Quinn   +4 more
openaire   +2 more sources

Differential outcomes of 609 rapid drug desensitization (RDD) for type I hypersensitivity to platins and taxanes [PDF]

Clin Transl Allergy, 2014
Caiado J, Mendes A, Pedro E, Barbosa M, Castells M.   +4 more
europepmc   +3 more sources

Does Rapid Drug Desensitization to Chemotherapy Affect Survival Outcomes? [PDF]

Journal of Investigational Allergology and Clinical Immunology, 2020
Hypersensitivity reactions to oxaliplatin may affect prognosis by jeopardizing the timely completion of scheduled treatment sessions or by forcing reactive patients into unexpected changes in therapy. Rapid drug desensitization (RDD) enables these patients to receive their first-choice treatments safely.
M P, Berges-Gimeno, L V, Carpio-Escalona, F, Longo-Muñoz, L, Bernal-Rubio, P, Lopez-Gonzalez, P, Gehlhaar, V, Pachon, R, Ferreiro-Monteagudo, R, Madrigal-Burgaleta, E, Alvarez-Cuesta   +9 more
openaire   +2 more sources

Rapid Desensitization in Immediate Hypersensitivity Reaction to Drugs [PDF]

Current Treatment Options in Allergy, 2015
Adverse drug reactions have increased dramatically worldwide, often preventing the use of first-line therapies. Not infrequently, many patients presenting with drug hypersensitivity reactions are irreversibly labeled as allergic, fact that prevents them to receive the most appropriate treatment for their illnesses. Rapid drug desensitization has become
Pedro Giavina-Bianchi, Marcelo Vivolo Aun, Violeta Régnier Galvão, Mariana Castells   +3 more
openaire   +1 more source

Preclinical discovery of duloxetine for the treatment of depression [PDF]

, 2012
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María, Elorza, Julián, Micó Segura, Juan Antonio, Perez-Caballero, Laura, Torres-Sanchez, Sonia   +4 more
core   +2 more sources

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT(3)) receptors ...
Aapro, Ahern, Amy Alexander, Andrew J. Samson, Bearcroft, Bertrand, Bertrand, Bhattacharyya, Boyd, Chanrion, Chen, Chen, Christopher Moffat, Christopher N. Connolly, Connolly, Craig, Faerber, Freeman, Galligan, Guthrie, Hagbom, Hanley, Hansen, Hothersall, Huang, Ilegems, J. Daniel Hothersall, Jiménez-Trejo, Karen A. Bollan, Kittler, Kondaurova, Lau, Lee, Linder, Liu, Liu, Lummis, McKinnon, Mercado, Minami, Mnie-Filali, Muchatuta, Niesler, Riad, Rojas, Schlag, Spiller, Stratz, Tao-Cheng, Turvill, Vikenes, Wade, Wesseldijk, Whalen, Yasuda   +54 more
core   +3 more sources