Results 1 to 10 of about 473,099 (191)

Desensitization: Overcoming the Immunologic Barriers to Transplantation [PDF]

Journal of Immunology Research, 2017
HLA (Human Leucocyte Antigen) sensitization is a significant barrier to successful kidney transplantation. It often translates into difficult crossmatch before transplant and increased risk of acute and chronic antibody mediated rejection after ...
Supreet Sethi, Jua Choi, Mieko Toyoda, Ashley Vo, Alice Peng, Stanley C. Jordan   +5 more
doaj   +5 more sources

Excellent outcome after desensitization in high immunologic risk kidney transplantation.

PLoS ONE, 2019
INTRODUCTION:HLA-incompatible (HLAi) and ABO-incompatible (ABOi) kidney transplantation (KT) has been on the increase over the last decade. However, there are wide variations in outcomes from these procedures.
Jeong-Hoon Lim, Jang-Hee Cho, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Eun Sang Yoo, Dong-Il Won, Chan-Duck Kim   +10 more
doaj   +5 more sources

Immunologic desensitization to nilotinib in a patient with chronic myeloid leukemia with hypersensitivity and complex comorbidities. [PDF]

J Allergy Clin Immunol Glob
Desensitization to nilotinib offers a viable solution for patients with chronic myeloid leukemia who are experiencing hypersensitivity, thus enabling continuation of targeted therapy.
Widagdo TSC, Fetarayani D, Nurani WK, Baskoro A, Soegiarto G.   +4 more
europepmc   +3 more sources

Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization [PDF]

Journal of Allergy and Clinical Immunology, 2011
Background There are no treatments currently available for peanut allergy. Sublingual immunotherapy is a novel approach to the treatment of peanut allergy.
Edwin H. Kim, J. Bird, M. Kulis, S. Laubach, L. Pons, W. Shreffler, Pamela H. Steele, J. Kamilaris, B. Vickery, A. Burks   +9 more
semanticscholar   +3 more sources

Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization [PDF]

Journal of Allergy and Clinical Immunology, 2019
Background: Peanut sublingual immunotherapy (SLIT) for 1 year has been shown to induce modest clinical desensitization in allergic children. Studies of oral immunotherapy, epicutaneous immunotherapy, and SLIT have suggested additional benefit with ...
Edwin H. Kim, Luanna Yang, Ping Ye, R. Guo, Quefeng Li, Michael Kulis, A. Burks   +6 more
semanticscholar   +3 more sources

Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates

Blood Advances, 2017
: The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound.
Jean Kwun, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, Alton B. Farris, Allan D. Kirk, Stuart J. Knechtle   +12 more
doaj   +2 more sources

Cassava oral immunotherapy in cassava-latex allergy: A pilot study [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: Cassava allergy is rare; however, because of the cross-reactivity of cassava with latex, it is clinically significant, affecting patient safety and quality of life. Oral immunotherapy (OIT) has been studied for use in patients with allergy to
Roberta Almeida Castro Araújo, MSc, MD, Claudia Leiko Yonekura Anagusko, MD, Paula Lazaretti Morato Castro, MD, Anne Karoline Rocha Medrado Ventura, PhD, Fábio Fernandes Morato Castro, PhD, MD, Jorge Elias Kalil Filho, PhD, MD, Keity Souza Santos, PhD, Ariana Campos Yang, PhD, MD   +7 more
doaj   +2 more sources

Immunologic observations during desensitization and maintenance of clinical tolerance to penicillin.

Journal of Allergy and Clinical Immunology, 1983
A nurse anesthetist who had experienced four systemic allergic reactions attributed to penicillin exposure was safely and successfully desensitized to penicillin despite predominantly minor determinant allergy (benzyl penicilloate skin test was positive at 1:100,000 dilution of standard 10 mM solution).
R. Naclerio, Edward A. Mizrahi, N. Adkinson   +2 more
semanticscholar   +3 more sources

Studies of desensitization and cross-desensitization to immunologic and nonimmunologic stimuli that evoke contraction and histamine release in superfused guinea pig trachea.

Journal of Allergy and Clinical Immunology, 1991
This study examined the possibility that there is cross-desensitization between immunologic and nonimmunologic stimuli that evoke contraction and histamine release (HR) in the isolated guinea pig trachea. Compound 48/80 and D-tubocurarine were found to cause homologous and heterologous desensitization for both contraction and HR from superfused trachea.
C. Buckner, J. Ro, J. Brendel, R. I. Fishleder, J. Will, R. Conklin, F. Graziano   +6 more
semanticscholar   +3 more sources

[Immunologic desensitization]. [PDF]

Duodecim lääketieteellinen aikakauskirja, 1998
E. Valovirta
semanticscholar   +2 more sources