Results 31 to 40 of about 4,642 (165)

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Nuevos esquemas de inmunoterapia específicas con alérgenos

Biomédica: revista del Instituto Nacional de Salud, 2010
Las enfermedades alérgicas, como el asma y la rinitis, son un problema de salud de importancia en todos los países y con una tendencia global al aumento en su prevalencia.
José Fernando Cantillo, Leonardo Puerta
doaj   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Use of Skin Testing Screening and Desensitization Before the First Exposure of Rituximab

Cancer Management and Research, 2021
Lisha Li,1 Lianglu Wang,1 Kai Guan,1 Jun Liu,1 Daobin Zhou,2 Yanbin Zhang,2 Yan Zhang2 1Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Precision ...
Li L, Wang L, Guan K, Liu J, Zhou D, Zhang Y, Zhang Y   +6 more
doaj  

Cheek tooth extraction in geriatric versus non‐geriatric horses

Equine Veterinary Journal, EarlyView.
Abstract Background Age‐related dental changes are major contributors to dental disorders in older horses, and cheek tooth extractions are often required to maintain masticatory function and oral comfort. However, limited information is available on clinical and treatment characteristics in this older patient population.
Elias Mair, Omid Nekouei, Patricia Trummer‐Schug, Rhea Haralambus, Nora Mareike Biermann   +4 more
wiley   +1 more source

Single‐stage orthognathic correction of campylorrhinus lateralis in foals using transection and fixation: Surgical description and outcome of four horses

Equine Veterinary Journal, EarlyView.
Abstract Background Campylorrhinus lateralis (‘wry nose’) is a rare congenital maxillofacial deformity of foals resulting in compromise of the airway and severe class 4 malocclusion. Various surgical techniques to correct the deformity have been described, but contemporary data on single‐stage transection and fixation, including use of a rib graft, and
Helio Vasco, Jim Schumacher, Jack Easley
wiley   +1 more source

Sesame Immunotherapy: A Systematic Review and Narrative Synthesis. [PDF]

Clin Transl Allergy
ABSTRACT Sesame allergy is associated with severe allergic reactions, low rates of spontaneous resolution, and significant psychosocial burden. Current management relies on strict avoidance and emergency treatment. Allergen‐specific immunotherapy, particularly oral immunotherapy (OIT), has emerged as a potential disease‐modifying approach, but evidence
Zielińska J, Kunkiel K, Krupa-Łaska A, Kulus M, Grzela K.   +4 more
europepmc   +2 more sources

Pancreatic α‐cell dysfunction associated with equine insulin dysregulation

Equine Veterinary Journal, EarlyView.
Abstract Background Insulin dysregulation (ID) in horses is characterised by insulin resistance and exaggerated insulin responses, yet the underlying endocrine mechanisms remain incompletely understood. In humans, α‐cell dysfunction characterised by exaggerated glucagon secretion contributes to metabolic disease; however, the role of pancreatic α‐cell ...
Sanna Lindåse, Emma Strage, Josefin Söder, Johan Bröjer   +3 more
wiley   +1 more source

Efficacy and safety of a house dust mites allergoid in patients with allergic rhinitis—PROACAROS study: protocol for a randomized controlled trial

Trials
Background There is an important heterogeneity of the clinical research done to date for allergen immunotherapy (AIT). We plan to assess the safety and efficacy of a house dust mite (HDM) polymerized allergen extract mixture for allergic ...
Inmaculada Buendía-Jiménez, María Matas-Ros, Teresa Garriga-Baraut, Albert Roger-Reig, Ana Tabar-Purroy, on behalf of the PROACAROS investigator group   +5 more
doaj   +1 more source

Effect of volume for injection of the 15th to 16th thoracic interspinous space: An ex vivo study

Equine Veterinary Journal, EarlyView.
Abstract Background Impinging (overriding) spinous processes (ISPs) are commonly identified in horses with back pain. Diagnostic analgesia is widely used as the clinical reference standard for confirming association with clinical signs of back pain, but the specificity of dorsal spinous region diagnostic analgesia remains poorly understood.
Virginia Melly, Kara A. Brown, Julie Engiles, Holly L. Stewart, Darko Stefanovski, Kathryn W. Bills, Elizabeth Davidson   +6 more
wiley   +1 more source