Results 21 to 30 of about 4,383 (197)

A Marine Analgesic Peptide, Contulakin-G, and Neurotensin are Distinct Agonists for Neurotensin Receptors: Uncovering Structural Determinants of Desensitization Properties

Frontiers in Pharmacology, 2015
Neurotensin receptors have been studied as molecular targets for the treatment of pain, schizophrenia, addiction, or cancer. Neurotensin (NT) and Contulakin-G, a glycopeptide isolated from a predatory cone snail Conus geographus, share a sequence ...
Hee-Kyoung eLee, Liuyin eZhang, Misty D Smith, Aleksandra eWalewska, Aleksandra eWalewska, Nadeem eVellore, Riccardo eBaron, J Michael eMcIntosh, H Steve eWhite, Baldomero M Olivera, Grzegorz eBulaj   +10 more
doaj   +1 more source

Clinical immunology review series: an approach to desensitization

Clinical and Experimental Immunology, 2010
Summary Allergen immunotherapy describes the treatment of allergic disease through administration of gradually increasing doses of allergen. This form of immune tolerance induction is now safer, more reliably efficacious and better understood than when it was first formally described in 1911.
M T, Krishna, A P, Huissoon
openaire   +3 more sources

Oral desensitizing treatment in food allergy: clinical and immunological results [PDF]

Alimentary Pharmacology & Therapeutics, 2003
SummaryBackground : The possibility of inducing oral desensitization in patients with food allergy is still controversial and no standardized programmes are yet available.Aim : To evaluate the safety and efficacy of oral desensitization in patients with allergy induced by the most common food allergens.Methods : Fifty‐nine patients with food allergy ...
Patriarca, Giampiero, Nucera, Eleonora, Roncallo, Chiara, Pollastrini, Emanuela, Bartolozzi, F, De Pasquale, Tiziana Maria, Buonomo, Alessandro, Gasbarrini, Giovanni Battista, Di Campli, Cristiana, Schiavino, Domenico   +9 more
openaire   +3 more sources

The Efficacy of a New Protocol of Oral Immunotherapy to Wheat for Desensitization and Induction of Tolerance

Iranian Journal of Allergy, Asthma and Immunology, 2022
Oral immunotherapy (OIT) is a novel approach to desensitization and tolerance induction in food allergy patients. This study aimed to design and implement a new wheat OIT protocol, evaluate its efficacy in tolerance induction, and assess specific ...
Samin Sharafian, Aliakbar Amirzargar, Mohammad Gharagozlou, Nima Parvaneh, Mansoureh Shariat, Marzieh Tavakol, Masoud Movahedi   +6 more
doaj   +1 more source

Sublingual immunotherapy for peanut allergy: Clinical and immunologic evidence of desensitization [PDF]

Journal of Allergy and Clinical Immunology, 2011
There are no treatments currently available for peanut allergy. Sublingual immunotherapy (SLIT) is a novel approach to the treatment of peanut allergy.We sought to investigate the safety, clinical effectiveness, and immunologic changes with SLIT in children with peanut allergy.In this double-blind, placebo-controlled study subjects underwent 6 months ...
Edwin H, Kim, J Andrew, Bird, Michael, Kulis, Susan, Laubach, Laurent, Pons, Wayne, Shreffler, Pamela, Steele, Janet, Kamilaris, Brian, Vickery, A Wesley, Burks   +9 more
openaire   +2 more sources

Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates

Blood Advances, 2017
: The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound.
Jean Kwun, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, Alton B. Farris, Allan D. Kirk, Stuart J. Knechtle   +12 more
doaj   +1 more source

Immunological barriers in ABO-incompatible kidney transplantation: How to overcome

Indian Journal of Transplantation, 2019
Background: Various desensitization strategies are used to overcome immunologic barriers such as anti-human leukocyte antigen-donor-specific antibody (HLA-DSA) and anti-ABO blood group incompatibility.
Sonia Mehrotra, Raj Kumar Sharma
doaj   +1 more source

A Review of Aspirin-exacerbated Respiratory Diseases and Immunological Efficacy of Aspirin Desensitization

Iranian Journal of Allergy, Asthma and Immunology, 2022
Aspirin-exacerbated respiratory disease (AERD) is a chronic inflammatory disease. It is defined by asthma, chronic rhinosinusitis with nasal polyposis, and a hypersensitivity reaction to aspirin or nonsteroidal anti-inflammatory drugs. Aspirin desensitization (AD) has been confirmed as an effective treatment to control AERD inflammation through the ...
Hossein Esmaeilzadeh, Maryam Zare, Soheila Alyasin, Hesamedin Nabavizadeh, Negar Mortazavi, Zahra Kanannejad   +5 more
openaire   +3 more sources

A practical view of immunotherapy for food allergy [PDF]

Korean Journal of Pediatrics, 2016
Food allergy is common and sometimes life threatening for Korean children. The current standard treatment of allergen avoidance and self-injectable epinephrine does not change the natural course of food allergy.
Tae Won Song
doaj   +1 more source

Immunotherapy in Allergic Fungal Sinusitis: The Controversy Continues. A Recent Review of Literature

Allergy & Rhinology, 2013
Allergic fungal sinusitis (AFS), also referred to as allergic fungal rhinosinusitis (AFRS), is a noninvasive, eosinophilic form of recurrent chronic allergic hypertrophic rhinosinusitis.
Mary S. Doellman D.O., Gregory R. Dion M.D., Erik Kent Weitzel M.D., Erika Gonzalez Reyes M.D.   +3 more
doaj   +1 more source