Results 11 to 20 of about 4,642 (165)

ABO Incompatible Kidney Transplantation—Current Status and Uncertainties

Journal of Transplantation, 2011
In the past, ABO blood group incompatibility was considered an absolute contraindication for kidney transplantation. Progress in defined desensitization practice and immunologic understanding has allowed increasingly successful ABO incompatible ...
Milljae Shin, Sung-Joo Kim
doaj   +1 more source

Desensitization: Overcoming the Immunologic Barriers to Transplantation

Journal of Immunology Research, 2017
HLA (Human Leucocyte Antigen) sensitization is a significant barrier to successful kidney transplantation. It often translates into difficult crossmatch before transplant and increased risk of acute and chronic antibody mediated rejection after ...
Supreet Sethi, Jua Choi, Mieko Toyoda, Ashley Vo, Alice Peng, Stanley C. Jordan   +5 more
doaj   +1 more source

Evaluación de la sensibilización a Der p 1 y Der p 2 en una población pediátrica del Norte de Portugal

Anales de Pediatría, 2018
Resumen: Introducción: En Portugal los datos del papel de Der p 1 y Der p 2 en niños con alergia al ácaro del polvo son escasos. La inmunoterapia específica (IE) con alérgenos es el único tratamiento que mejora los síntomas, reduce la necesidad de ...
Sara Peixoto, Joana Soares, Tânia Monteiro, Marisa Carvalho, Marinela Santos, Carla Simões, Márcia Quaresma   +6 more
doaj   +1 more source

A Marine Analgesic Peptide, Contulakin-G, and Neurotensin are Distinct Agonists for Neurotensin Receptors: Uncovering Structural Determinants of Desensitization Properties

Frontiers in Pharmacology, 2015
Neurotensin receptors have been studied as molecular targets for the treatment of pain, schizophrenia, addiction, or cancer. Neurotensin (NT) and Contulakin-G, a glycopeptide isolated from a predatory cone snail Conus geographus, share a sequence ...
Hee-Kyoung eLee, Liuyin eZhang, Misty D Smith, Aleksandra eWalewska, Aleksandra eWalewska, Nadeem eVellore, Riccardo eBaron, J Michael eMcIntosh, H Steve eWhite, Baldomero M Olivera, Grzegorz eBulaj   +10 more
doaj   +1 more source

The Efficacy of a New Protocol of Oral Immunotherapy to Wheat for Desensitization and Induction of Tolerance

Iranian Journal of Allergy, Asthma and Immunology, 2022
Oral immunotherapy (OIT) is a novel approach to desensitization and tolerance induction in food allergy patients. This study aimed to design and implement a new wheat OIT protocol, evaluate its efficacy in tolerance induction, and assess specific ...
Samin Sharafian, Aliakbar Amirzargar, Mohammad Gharagozlou, Nima Parvaneh, Mansoureh Shariat, Marzieh Tavakol, Masoud Movahedi   +6 more
doaj   +1 more source

Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates

Blood Advances, 2017
: The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound.
Jean Kwun, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, Alton B. Farris, Allan D. Kirk, Stuart J. Knechtle   +12 more
doaj   +1 more source

Excellent outcome after desensitization in high immunologic risk kidney transplantation.

PLoS ONE, 2019
INTRODUCTION:HLA-incompatible (HLAi) and ABO-incompatible (ABOi) kidney transplantation (KT) has been on the increase over the last decade. However, there are wide variations in outcomes from these procedures.
Jeong-Hoon Lim, Jang-Hee Cho, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Eun Sang Yoo, Dong-Il Won, Chan-Duck Kim   +10 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Immunological barriers in ABO-incompatible kidney transplantation: How to overcome

Indian Journal of Transplantation, 2019
Background: Various desensitization strategies are used to overcome immunologic barriers such as anti-human leukocyte antigen-donor-specific antibody (HLA-DSA) and anti-ABO blood group incompatibility.
Sonia Mehrotra, Raj Kumar Sharma
doaj   +1 more source

A practical view of immunotherapy for food allergy [PDF]

Korean Journal of Pediatrics, 2016
Food allergy is common and sometimes life threatening for Korean children. The current standard treatment of allergen avoidance and self-injectable epinephrine does not change the natural course of food allergy.
Tae Won Song
doaj   +1 more source