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Food oral immunotherapy [PDF]

Allergy, Asthma & Clinical Immunology
Food oral immunotherapy (OIT) is an option for the treatment of immunoglobin E (IgE)‐mediated food allergy that involves administering gradually increasing doses of an allergenic food over time (under medical supervision) with the goal of desensitizing ...
Mary McHenry, Philippe Bégin, Edmond S. Chan, Meriem Latrous, Harold Kim   +4 more
doaj   +4 more sources

Food allergy immunotherapy: Oral immunotherapy and epicutaneous immunotherapy [PDF]

Allergy: European Journal of Allergy and Clinical Immunology, 2020
AbstractIgE‐mediated food allergy remains a significant and growing problem across the globe. Of the various treatment modalities, oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) have been the best studied. Across various studies of OIT for egg, milk, and peanut allergy, strong levels of desensitization have been shown.
Edwin H Kim, A Wesley Burks
exaly   +3 more sources

Real-life safety of peanut oral immunotherapy: Results from a French multicenter observational study [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: Peanut oral immunotherapy (POIT) has been widely used in France for more than 10 years. However, the overall “real-life” safety of POIT has not been evaluated to date.
Elodie Michaud, MD, Flore Amat, MD, PhD, Dr Habil, Céline Lambert, MSc, Amandine Divaret-Chauveau, PhD, Antoine Deschildre, Pr, A. Nemni, M. Voidey, T. Moraly, P. Bierme, D. Sabouraud, L. Couderc, D. Caimmi, A. Dupré Latour   +12 more
doaj   +2 more sources

Immunotherapy and Oral Immunotherapy with Omalizumab for Food Allergies

European Medical Journal, 2019
Food allergy is potentially life-threatening and has a major impact on quality of life. Avoidance is currently the only approved therapy, and, although effective, avoidance diets can be difficult and may also put children at risk of nutritional ...
Shoichiro Taniuchi, Masahiro Enomoto, Hirotaka Minami   +2 more
doaj   +2 more sources

Safer oral immunotherapy with very low-dose introduction for pediatric hen’s egg allergy [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: Adverse events could be a barrier to implementing oral immunotherapy (OIT) in children with hen’s egg (HE) allergy, highlighting the need for safer OIT methods.
Fumi Ishikawa, MD, Yumiko Miyaji, MD, PhD, Kiwako Yamamoto-Hanada, MD, PhD, Mami Shimada, MD, Tomoyuki Kiguchi, MD, Seiko Hirai, MD, Yuri Endo Kram, MD, Kazuma Takada, MD, Kyoko Noguchi, MD, Yusuke Inuzuka, MD, Kenji Toyokuni, MD, PhD, Mayako Saito-Abe, MD, PhD, Miori Sato, MD, Shigenori Kabashima, MD, PhD, Kyongsun Pak, PhD, Eisuke Inoue, PhD, Tatsuki Fukuie, MD, PhD, Yukihiro Ohya, MD, PhD   +17 more
doaj   +2 more sources

Oral immunotherapy for cow’s milk allergy in children: a systematic review and meta-analysis [PDF]

Frontiers in Immunology
ObjectiveCow’s milk allergy (CMA) is one of the most common causes of food allergies (FA) in children. There have been studies on the use of immunotherapy in cow’s milk protein allergy, with oral immunotherapy (OIT) being the most extensively researched.
Yan Wang, Yan Wang, Shunli Liu, Shunli Liu, Meizhu Lu, Meizhu Lu, Jingyu Guo, Jingyu Guo, Can Lv, Can Lv, Lan Huang, Lan Huang   +11 more
doaj   +2 more sources

Elucidation of Desensitization Mechanisms Induced by Oral Immunotherapy in a Rat Model of Ovalbumin Allergy [PDF]

Foods
Oral immunotherapy (OIT) is a promising approach for treating food allergy. Here, we elucidated the mechanisms of desensitization induced by OIT in rats sensitized to ovalbumin (OVA).
Daigo Takizawa, Tomoharu Yokooji, Chika Miyamoto, Yuki Koga, Keisuke Oda, Ryohei Ogino, Takanori Taogoshi, Hiroaki Matsuo   +7 more
doaj   +2 more sources

Trends in allergen-reactive CRTH2+ T cells and TARC associated with successful outcomes in a phase 2 cashew oral immunotherapy study [PDF]

Frontiers in Immunology
BackgroundWe designed an oral immunotherapy (OIT) clinical trial for cashew allergy to further our understanding of immunological responses with treatment, including changes in allergen-specific T cells.
Sayantani B. Sindher, Andrea Fernandes, Monali Manohar, Shu Cao, Sheena Gupta, Sheena Gupta, Ella Parsons, Dinara Bogetic, Divya Kumar, Jessica Rogers, Julia Thompson, Diane Dunham, Evan Do, Sofia Maysel-Auslender, Taryn Audrey Liu, Kristine Martinez, Brent Anderson, Abhinav Kaushik, Manisha Desai, Holden Maecker, Holden Maecker, Susan Perry, Lisa M. Wheatley, Kari C. Nadeau, Kari C. Nadeau, R. Sharon Chinthrajah   +25 more
doaj   +2 more sources

Knocking-Down CD147/EMMPRIN Expression in CT26 Colon Carcinoma Forces the Cells into Cellular and Angiogenic Dormancy That Can Be Reversed by Interactions with Macrophages

Biomedicines, 2023
Metastasis in colorectal cancer is responsible for most of the cancer-related deaths. For metastasis to occur, tumor cells must first undergo the epithelial-to-mesenchymal transition (EMT), which is driven by the transcription factors (EMT-TFs) Snail ...
Gabriele Feigelman, Elina Simanovich, Phillipp Brockmeyer, Michal A. Rahat   +3 more
doaj   +1 more source

Biomarkers in oral immunotherapy

Journal of Zhejiang University-SCIENCE B, 2022
Food allergy (FA) is a global health problem that affects a large population, and thus effective treatment is highly desirable. Oral immunotherapy (OIT) has been showing reasonable efficacy and favorable safety in most FA subjects. Dependable biomarkers are needed for treatment assessment and outcome prediction during OIT.
Haitao Zhu, Kaifa Tang, Guoqiang Chen, Zhongwei Liu   +3 more
openaire   +2 more sources