Results 21 to 30 of about 1,518,868 (239)

Peanut allergy: Beyond the oral immunotherapy plateau

Clinical and Translational Allergy, 2021
Background There are a lack of disease‐modifying treatments for peanut allergy, which is lifelong in most instances. Oral immunotherapy has remained at the forefront of prospective treatments, though its efficacy is consistently undermined by the risk of
Kelly Bruton, Paul Spill, Derek K. Chu, Susan Waserman, Manel Jordana   +4 more
doaj   +1 more source

Clinical effectiveness of hymenoptera venom immunotherapy [PDF]

, 2013
Treatment failure during venom immunotherapy (VIT) may be associated with a variety of risk factors. Our aim was to evaluate the association of baseline serum tryptase concentration (BTC) and of other parameters with the frequency of VIT failure during ...
Scheipl, Fabian, Darsow, Ulf, Reider, Norbert, Bonifazi, Floriano, Aberer, Werner, Schmid-Grendelmeier, Peter, Ruëff, Franziska, Treudler, Regina, Biló, Maria Beatrice, Sturm, Gunter Johannes, Küchenhoff, Helmut, Severino, Maurizio, Wüthrich, Brunello, Seitz, Michael J., Quercia, Oliviero, Bodzenta-Lukaszyk, Anna, Lang, Roland, Haeberli, Gabrielle, Campi, Paolo, Hawranek, Thomas, Müller, Ulrich, Przybilla, Bernhard   +21 more
core   +1 more source

Eosinophilic Esophagitis as a Side Effect of Food Oral Immunotherapy

Medicina, 2020
Food allergies (FAs) include a spectrum of immune-mediated serious and potentially life-threatening medical conditions with an overall estimated prevalence ranging from 4% to 8% in the U.S. and Europe.
Antonella Cianferoni
doaj   +1 more source

Immune mechanisms of oral immunotherapy [PDF]

Journal of Allergy and Clinical Immunology, 2018
Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms
Vickery, Brian P., Patil, Sarita U., Kulis, Michael D., Wambre, Erik   +3 more
openaire   +2 more sources

IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy

Frontiers in Allergy, 2023
BackgroundOral immunotherapy (OIT) with peanut (Arachis hypogaea) allergen powder-dnfp (PTAH; Aimmune Therapeutics) is an FDA-approved treatment to desensitize peanut allergic participants.ObjectiveHere we assessed shifts in IgE and IgG4 binding to ...
Ian M. Rambo, Christina M. Kronfel, Adam R. Rivers, Lauren T. Swientoniewski, Jane K. McBride, Hsiaopo Cheng, Reyna J. Simon, Robert Ryan, Stephen A. Tilles, Jacqueline B. Nesbit, Michael D. Kulis, Barry K. Hurlburt, Soheila J. Maleki   +12 more
doaj   +1 more source

Food allergy oral immunotherapy

Journal of Food Allergy, 2020
Food allergy oral immunotherapy (OIT) has demonstrated efficacy in promoting clinically relevant immunomodulation that leads to desensitization (reduced reactivity while on OIT) in the majority of treated individuals; however, sustained unresponsiveness after OIT cessation for a specified interval has only been observed in a subset.
Sood, Amika K., Scurlock, Amy M.
openaire   +2 more sources

Effect of Oral Immunotherapy on Nasal Blockage in Experimental Allergic Rhinitis

Journal of Pharmacological Sciences, 2005
We previously reported that when Japanese cedar pollen was prophylactically p.o. administered before a sensitization stage in a guinea-pig model of allergic rhinitis, pollen-induced nasal blockage was suppressed.
Takeshi Nabe, Kayoko Kubota, Tetsuya Terada, Hiroshi Takenaka, Shigekatsu Kohno   +4 more
doaj   +1 more source

Eosinophils in Eosinophilic Esophagitis: The Road to Fibrostenosis is Paved With Good Intentions

Frontiers in Immunology, 2020
Eosinophilic esophagitis (EoE) is an antigen-driven disease associated with epithelial barrier dysfunction and chronic type 2 inflammation. Eosinophils are the defining feature of EoE histopathology but relatively little is known about their role in ...
Alfred D. Doyle, Mia Y. Masuda, Hirohito Kita, Hirohito Kita, Benjamin L. Wright, Benjamin L. Wright   +5 more
doaj   +1 more source

New modalities of allergen immunotherapy

Human Vaccines & Immunotherapeutics, 2018
Allergen immunotherapy is a rapidly evolving field. Although subcutaneous immunotherapy has been practiced for over a hundred years, improved understanding of the underlying immunological mechanisms has led to the development of new, efficacious and ...
Manish Ramesh, Merhunisa Karagic
doaj   +1 more source

Mechanisms of desensitization with oral immunotherapy and epicutaneous immunotherapy

Journal of Food Allergy, 2023
Background: Oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) are emerging therapies for food allergy. With several recently published exploratory trials and randomized controlled clinical trials that support these procedures, there is a clear progress and interest toward making these treatment options available for allergist ...
openaire   +2 more sources