Results 21 to 30 of about 86,557 (257)

Eosinophilic Esophagitis as a Side Effect of Food Oral Immunotherapy

Medicina, 2020
Food allergies (FAs) include a spectrum of immune-mediated serious and potentially life-threatening medical conditions with an overall estimated prevalence ranging from 4% to 8% in the U.S. and Europe.
Antonella Cianferoni
doaj   +1 more source

IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy

Frontiers in Allergy, 2023
BackgroundOral immunotherapy (OIT) with peanut (Arachis hypogaea) allergen powder-dnfp (PTAH; Aimmune Therapeutics) is an FDA-approved treatment to desensitize peanut allergic participants.ObjectiveHere we assessed shifts in IgE and IgG4 binding to ...
Ian M. Rambo, Christina M. Kronfel, Adam R. Rivers, Lauren T. Swientoniewski, Jane K. McBride, Hsiaopo Cheng, Reyna J. Simon, Robert Ryan, Stephen A. Tilles, Jacqueline B. Nesbit, Michael D. Kulis, Barry K. Hurlburt, Soheila J. Maleki   +12 more
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Oral Immunotherapy for Food Allergies [PDF]

Annals of Nutrition and Metabolism, 2016
Oral immunotherapy (OIT) is a promising investigational therapy for food allergy. Clinical trials in peanut, milk, egg, and wheat allergy provide evidence that OIT can effectively desensitize a majority of individuals to a food allergen. While a portion of subjects demonstrate sustained unresponsiveness, the majority regain sensitivity with allergen ...
Elizabeth, Feuille, Anna, Nowak-Węgrzyn
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Food allergy oral immunotherapy

Journal of Food Allergy, 2020
Food allergy oral immunotherapy (OIT) has demonstrated efficacy in promoting clinically relevant immunomodulation that leads to desensitization (reduced reactivity while on OIT) in the majority of treated individuals; however, sustained unresponsiveness after OIT cessation for a specified interval has only been observed in a subset.
Sood, Amika K., Scurlock, Amy M.
openaire   +2 more sources

Effect of Oral Immunotherapy on Nasal Blockage in Experimental Allergic Rhinitis

Journal of Pharmacological Sciences, 2005
We previously reported that when Japanese cedar pollen was prophylactically p.o. administered before a sensitization stage in a guinea-pig model of allergic rhinitis, pollen-induced nasal blockage was suppressed.
Takeshi Nabe, Kayoko Kubota, Tetsuya Terada, Hiroshi Takenaka, Shigekatsu Kohno   +4 more
doaj   +1 more source

Eosinophils in Eosinophilic Esophagitis: The Road to Fibrostenosis is Paved With Good Intentions

Frontiers in Immunology, 2020
Eosinophilic esophagitis (EoE) is an antigen-driven disease associated with epithelial barrier dysfunction and chronic type 2 inflammation. Eosinophils are the defining feature of EoE histopathology but relatively little is known about their role in ...
Alfred D. Doyle, Mia Y. Masuda, Hirohito Kita, Hirohito Kita, Benjamin L. Wright, Benjamin L. Wright   +5 more
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Mechanisms of desensitization with oral immunotherapy and epicutaneous immunotherapy

Journal of Food Allergy, 2023
Background: Oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) are emerging therapies for food allergy. With several recently published exploratory trials and randomized controlled clinical trials that support these procedures, there is a clear progress and interest toward making these treatment options available for allergist ...
openaire   +2 more sources

Peanut allergy and oral immunotherapy [PDF]

Hong Kong Medical Journal, 2019
Peanut allergy is the commonest cause of food-induced anaphylaxis in the world, and it can be fatal. There have been many recent improvements to achieve safe methods of peanut desensitisation, one of which is to use a combination of anti-immunoglobulin E and oral immunotherapy.
T H, Lee, J K C, Chan, P C, Lau, W P, Luk, L H, Fung   +4 more
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New modalities of allergen immunotherapy

Human Vaccines & Immunotherapeutics, 2018
Allergen immunotherapy is a rapidly evolving field. Although subcutaneous immunotherapy has been practiced for over a hundred years, improved understanding of the underlying immunological mechanisms has led to the development of new, efficacious and ...
Manish Ramesh, Merhunisa Karagic
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The Anti-EMMPRIN Monoclonal Antibody hMR18-mAb Induces Tumor Dormancy and Inhibits the EMT Process in Human Carcinoma Cell Lines Co-Cultured with Macrophages

Biomedicines
Background: The epithelial-to-mesenchymal transition (EMT) process is necessary for metastasis as it enables tumor cells’ migration and invasion. In the remote organ, tumor cells can develop into metastatic lesions or arrest their proliferation and ...
Elina Simanovich, Felix Oyelami, Phillipp Brockmeyer, Michal A. Rahat   +3 more
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