Results 31 to 40 of about 86,557 (257)

The Nuts and Bolts of Food Immunotherapy: The Future of Food Allergy

Children, 2018
Food allergies are on the rise and have a major impact on the quality of life of the food allergic child and their family. Currently, the mainstream treatment for food allergies is strict avoidance and elimination of the allergenic food(s) from the ...
Sara Anvari, Katherine Anagnostou
doaj   +1 more source

Immune mechanisms of oral immunotherapy [PDF]

Journal of Allergy and Clinical Immunology, 2018
Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms
Vickery, Brian P., Patil, Sarita U., Kulis, Michael D., Wambre, Erik   +3 more
openaire   +2 more sources

Clinical and histopathological features of the first known case of glycogenic acanthosis resembling an isolated gingival tumour: A case report

Oral and Maxillofacial Surgery Cases
Glycogenic acanthosis is a common benign lesion of the oesophagus. However, extra-oesophageal localisations in the larynx and oral mucosa in the form of white, papular or plaque-like lesions are possible.
Svyat Strokov, Anne-Laure Ejeil, Hélène Raybaud, Christine Voha, Sophie-Myriam Dridi   +4 more
doaj   +1 more source

Bypassing the build-up phase for oral immunotherapy in shrimp-allergic children

World Allergy Organization Journal
Background: Oral immunotherapy is an effective treatment for food allergies; however, its use in clinical practice is limited by resources and lack of standardized protocols for foods other than peanut.
Ann-Marie M. Schoos, MD, PhD, DMSc, Edmond S. Chan, MD, Tiffany Wong, MD, Stephanie C. Erdle, MD, Alanna Chomyn, MD, Lianne Soller, PhD, Raymond Mak, MD   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Failed oral immunotherapy should be considered as a risk factor for fatal anaphylaxis, and omalizumab treatment considered

Italian Journal of Pediatrics
Oral immunotherapy is proposed as the only active intervention to modify allergies and decrease the risk of severe reactions. However, it is crucial to note that oral immunotherapy still presents a notable failure rate and potential for severe, life ...
Francesca Nicolardi, Federica Corona, Laura Badina, Irene Berti, Egidio Barbi   +4 more
doaj   +1 more source

Oral immunotherapy for milk allergy

Cochrane Database of Systematic Reviews, 2012
The mainstay of treatment of IgE-mediated cow milk allergy (IMCMA) is an avoidance diet, which is especially difficult with a ubiquitous food like milk. Milk oral immunotherapy (MOIT) may be an alternative treatment, through desensitization or induction of tolerance.We aim to assess the clinical efficacy and safety of MOIT in children and adults with ...
Joanne P, Yeung, Lorie A, Kloda, Jason, McDevitt, Moshe, Ben-Shoshan, Reza, Alizadehfar   +4 more
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Children and caregiver proxy quality of life from peanut oral immunotherapy trials

Clinical and Translational Allergy, 2022
Background Health‐related quality of life (HRQoL) is significantly and substantially reduced in individuals with peanut allergy due to many factors associated with unanticipated or potentially fatal reactions. Further insight on the impact of peanut oral
Audrey Dunn Galvin, Andrea Vereda, Pablo Rodríguez delRío, Antonella Muraro, Carla Jones, Robert Ryan, David Norval, Jennifer Jobrack, Aikaterini Anagnostou, Julie Wang   +9 more
doaj   +1 more source