Results 51 to 60 of about 36,635 (234)

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]

, 2014
Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chen, Chao-Yin, Hell, Johannes Wilhelm, Matt, Lucas, Rogawski, Michael A   +3 more
core   +3 more sources

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, EarlyView.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

GABAB receptor allosteric modulators exhibit pathway-dependent and species-selective activity. [PDF]

, 2017
Positive modulation of the GABAB receptor (GABABR) represents a potentially useful therapeutic approach for the treatment of nicotine addiction. The positive allosteric modulators (PAMs) of GABABR GS39783 and BHF177 enhance GABA-stimulated [35S]GTP γS ...
Cameron, Michael, de Lourdes Ladino, Maria, Finn, MG, Griffin, Patrick R, Kaczanowska, Kasia, Li, Xia, Markou, Athina, McDonald, Patricia, Sturchler, Emmanuel   +8 more
core   +1 more source

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, EarlyView.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway [PDF]

, 2009
These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional α4β2* nAChRs in the nigrostriatal dopaminergic (DA) pathway.
Cai, Haijiang, Lester, Henry A., McIntosh, J. Michael, McKinney, Sheri, Nashmi, Raad, Xiao, Cheng   +5 more
core  

Ülitundlikkusreaktsioonid kemoteraapiale ja desensibiliseeriv ravi [PDF]

, 2017
Järjest suurenev kasvajavastase ravi kasutamine viimaste kümnendite jooksul on suurendanud ka erinevate kõrvaltoimete esinemist. Ülitundlikkusreaktsioonid kemoteraapilistele ravimitele, sh monokloonsetele antikehadele, põhjustavad sageli patsiendi ...
Ress, Krista
core   +2 more sources

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Molar incisor hypomineralisation: current knowledge and practice

International Dental Journal, EarlyView., 2020
Background Molar incisor hypomineralisation (MIH) is a common developmental dental condition that presents in childhood. Areas of poorly formed enamel affect one or more first permanent molars and can cause opacities on the anterior teeth. MIH presents a variety of challenges for the dental team as well as functional and social impacts for affected ...
Helen D. Rodd, Anna Graham, Niecoo Tajmehr, Laura Timms, Noren Hasmun   +4 more
wiley   +1 more source

Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function [PDF]

, 2018
Visual function in vertebrates critically depends on the continuous regeneration of visual pigments in rod and cone photoreceptors. RPE65 is a well-established retinoid isomerase in the pigment epithelium that regenerates rhodopsin during the rod visual ...
Angueyra, Juan M, Badiee, Mohsen, Kefalov, Vladimir J, Kinoshita, Junzo, Kiser, Philip D, Kolesnikov, Alexander V, Li, Wei, Palczewski, Krzysztof, Peachey, Neal S, Sharma, Aditya, Tochtrop, Gregory P, Zhang, Jianye   +11 more
core   +1 more source