Results 81 to 90 of about 6,513,025 (253)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Procedures in emergency medicine: surgical cricothyroidotomy

, 2013
This video is part of a series of videos demonstrating common procedures performed in the Emergency Medicine setting. It was prepared by Cape Town Emergency Medicine's consultants and registrars.
Oosthuizen, Almero, Cape Town Emergency Medicine Registrars   +1 more
core   +1 more source

emergency departments

, 2023
Objectives: Frailty is a clinical syndrome characterized by decreased physiologic reserve that diminishes the ability to respond to stressors such as acute illness.
Carrie Ballard, Hastings, S. Nicole, James E. Slaven, Ballard, Carrie, Sharmistha Dev, Coffing, Jessica, Dawn M. Bravata, Bravata, Dawn M., Taylor, Stan, Slaven, James E, Dev, Shantanu, S. Nicole Hastings, Andrew A. Gonzalez, Bravata, Dawn M, Jessica Coffing, Hastings, S Nicole, Gonzalez, Andrew A., Gonzalez, Andrew A, Dev, Sharmistha, Slaven, James E., Shantanu Dev, Stan Taylor   +21 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Procedures in emergency medicine: needle cricothyroidotomy

, 2013
This video is part of a series of videos demonstrating common procedures performed in the Emergency Medicine setting. It was prepared by Cape Town Emergency Medicine's consultants and registrars.
Oosthuizen, Almero, Cape Town Emergency Medicine Registrars   +1 more
core   +1 more source

Is Emergency Medicine the Right Choice for Me? [PDF]

, 2019
One of the hardest decisions a medical student has to make is the choice of specialty. Many studies have explored what influences the choice of emergency medicine (EM) as a specialty.
Schofer, Joel M., Asher, Shellie L., Rosen, Brett, Rosen, Peter L., Wald, David A., Kazzi, Amin Antoine Nabih, Cheaito, Mohamad Ali, Epter, Michael L.   +7 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Faculty Mentoring Practices in Academic Emergency Medicine [PDF]

, 2017
Background Mentoring is considered a fundamental component of career success and satisfaction in academic medicine. However, there is no national standard for faculty mentoring in academic emergency medicine (EM) and a paucity of literature on the ...
Hockberger, Robert, Rusyniak, Daniel, Ownbey, Misha, Sawtelle, Stacy, Welch, Julie, Perkins, Tony, Cheng, David, MacNeill, Emily   +7 more
core   +1 more source

COMBINATION OF LACTATE WITH MODIFIED EARLY WARNING SCORE AND RAPID EMERGENCY MEDICINE SCORE IN GERIATRIC PATIENTS ADMITTED TO EMERGENCY DEPARTMENT TO PREDICT 28-DAY MORTALITY

Turkish Journal of Geriatrics, 2018
Introduction: Aim was to compare the efficacy of Rapid Emergency Medicine Score, Rapid Emergency Medicine Score-Lactate, Modified Early Warning Score and Modified Early Warning Score-Lactate scores in predicting 28-day mortality after emergency department visit and hospitalization from emergency department for patients with age ≥65 years. Materials and
Kurtoglu Celik, GÜLHAN, Demircan, Serkan, Gokhan, Servan, Ozhasenekler, Ayhan, Tanriverdi, Fatih, Elgormus, Cagri Serdar, Ergin, Mehmet   +6 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source