Results 91 to 100 of about 186,072 (301)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Upper-tropospheric potential vorticity anomaly before the rapid intensification of Typhoon Mujigae (2015) and its response to reduced SST

Atmospheric and Oceanic Science Letters, 2020
As the strongest typhoon in 2015, the rapid intensification (RI) process of Typhoon Mujigae is simulated at the cloud-resolving scale by utilizing the Weather Research and Forecasting model, coupled with observed sea surface temperature (SST) and reduced
Xiba TANG, Shuai YANG, Fan PING, Jing PENG   +3 more
doaj   +1 more source

The Braer storm revisited [PDF]

, 2013
The Braer storm of January 1993 was the deepest ever recorded cyclone outside of the Tropics with a minimum core pressure of 914mbar, but due to its track between Scotland and Iceland it caused little damage and was never intensively examined.
Knippertz, P, Odell, L, Parkes, B, Pickering, S, Roberts, A   +4 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The Relative Importance of Factors Influencing Tropical Cyclone Rapid Intensity Changes

Geophysical Research Letters, 2019
Predicting rapid intensity changes in tropical cyclones (TCs) is a major challenge due to the influence of multiple competing processes within the vortex and in the TC environment. We present an empirical framework that quantifies the relative importance
Sai Prasanth, Ziad S. Haddad, Svetla M. Hristova‐Veleva, F. D. Marks Jr.   +3 more
doaj   +1 more source

Dynamic Forcing Behind Rapid Intensification of Hurricane Lidia

This study examines Hurricane Lidia rapid intensification (RI) in the understudied northeastern Pacific, focusing on its interaction with an upper-level trough. Using IFS-ECMWF ensemble forecasts and ERA5 reanalysis, we analyze the large-scale dynamical mechanisms driving Lidias intensification.
López-Reyes, Mauricio, Martín-Pérez, M. L., Calvo-Sancho, C., González-Alemán, J. J.   +3 more
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Amplified Bimodal Distribution of Western North Pacific Tropical Cyclone Lifetime Maximum Intensity

Geophysical Research Letters
The impact of a warming climate on tropical cyclones (TCs) remains unclear. Here, we find that the probability density function for western North Pacific TC lifetime maximum intensity (LMI) has an amplified bimodal distribution in recent years.
Qian Xiang, Haikun Zhao, Philip J. Klotzbach, Tonghua Su, Chao Wang, Liguang Wu   +5 more
doaj   +1 more source