Results 191 to 200 of about 1,890,575 (267)

Malaria infection prevalence and diagnostic performance of the Abbott Bioline Malaria Ag P.f/Pan rapid test in rural populations of Central Cameroon. [PDF]

Sci Rep
Missoup VO, Suh PF, Ndjebakal CN, Tagne D, Poumachu Y, Joko S, Kouamendjouo Djilla A, Njiokou F, Mbacham W, Wondji C, Ndo C.   +10 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Clinical development and performance of the First to Know Syphilis Self-Test for over-the-counter usage: a <i>de novo</i> rapid test for treponemal antibody. [PDF]

J Clin Microbiol
Clark K, Joyee AG, Biddison D, Rabine S, Qian J, Spradlin S, Thompson V, Shi Q, Xu J, Zhang L, Brown A, Nibauer L, Pillai R, Berry JD.   +13 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Detection of SARS-CoV-2 Using the Abbott™ PANBIO™ COVID-19 SELF-TEST Rapid Test in Patients Seen at INER. [PDF]

Biomedicines
Cantón Cruz KA, Durán Barrón MA, Morales Lozada IA, Mujica Sánchez MA, Deloya Brito GG, García Colín MDC, Chávez Morales HH, Aguirre Pineda JN, Cid Del Prado Rojas CK, Valdés SJ, Becerril Vargas E.   +10 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

False Positive for Malaria Rapid Test in a Patient With Cytomegalovirus Infection. [PDF]

Cureus
Prieto-Torres AE, Katime Zuñiga A, Lacouture Ortiz B, Faccini-Martínez ÁA.   +3 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

The NitroSpeed Taniborbactam NP test as a rapid test for detection of β-lactamase-mediated susceptibility to taniborbactam. [PDF]

FEMS Microbiol Lett
Raro OHF, Herrera-Espejo S, Bouvier M, Kerbol A, Poirel L, Nordmann P.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source