Results 71 to 80 of about 4,554,614 (308)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Development of a rapid lateral flow immunoassay test for detection of exosomes previously enriched from cell culture medium and body fluids [PDF]

Journal of Extracellular Vesicles, 2016
Exosomes are cell-secreted nanovesicles (40–200 nm) that represent a rich source of novel biomarkers in the diagnosis and prognosis of certain diseases.
Myriam Oliveira-Rodríguez, Sheila López-Cobo, Hugh T. Reyburn, Agustín Costa-García, Soraya López Martín, María Yáñez Mo, Eva Cernuda-Morollón, Annette Paschen, Mar Valés-Gómez, Maria Carmen Blanco-López   +9 more
doaj   +1 more source

Nilai Diagnostik Leprosy Rapid Test untuk Menegakkan Diagnosis Morbus Hansen [PDF]

, 2015
Morbus Hansen (MH) masih merupakan masalah kesehatan serius. Gambaran klinis MH yang luas menyebabkan diagnosis MH sulit dibangun. Penegakan diagnosis MH secara akurat penting dalam memutuskan rantai transmisi dan keterlambatan pengobatan.
Rusawardiana, R. (Rusawardiana), Suhardi, S. (Silvi), Thaha, A. (Athuf), Tjekyan, R. M. (R)   +3 more
core  

Molecular analysis of PKU-associated PAH mutations: a fast and simple genotyping test [PDF]

, 2018
: Neonatal screening for phenylketonuria (PKU, OMIM: 261600) was introduced at the end of the 1960s. We developed a rapid and simple molecular test for the most frequent phenylalanine hydroxylase (PAH, Gene ID: 5053) mutations.
Antonio Angeloni, ARTIOLA, CRISTIANA, CARDUCCI, Carla, CARDUCCI, Claudia, D'AMICI, SIRIO, GIOVANNIELLO, TERESA, Manuela Tolve, PASQUALI, Amelia, PIZZUTI, Antonio, Vincenzo Leuzzi   +9 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Canine Trypanosoma cruzi infection in the Bolivian Chaco [PDF]

, 2018
A cross-sectional study on Trypanosoma cruzi was carried out in 2013 to evaluate the role of dogs as possible source of infection for humans in two rural communities of the highly endemic Bolivian Chaco (Bartolo, Chuquisaca Department, n = 57 dogs; and ...
Bartoloni, Alessandro, Cancrini, Gabriella, Gabrielli, Simona, Gamboa, Herlan, Macchioni, Fabio, Rojas, Patricia, Rojo, David, Roselli, Mimmo, Spinicci, Michele, Totino, Valentina   +9 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Viral Hepatitis and Rapid Diagnostic Test Based Screening for HBsAg in HIV-infected Patients in Rural Tanzania. [PDF]

, 2013
\ud \ud Co-infection with hepatitis B virus (HBV) is highly prevalent in people living with HIV in Sub-Saharan Africa. Screening for HBV surface antigen (HBsAg) before initiation of combination antiretroviral therapy (cART) is recommended. However, it is
AM Geretti, AP Kourtis, AS Lok, Bernadeta Msongole, BH Tess, Bruno Verhasselt, Christoph Hatz, CJ Hoffmann, CJ Hoffmann, CL Thio, D Nash, E Mossdorf, E Stahel, ED Chan, Emilio Letang, F Randrianirina, Fabian C. Franzeck, Geoffrey Mwaigomole, GV Matthews, J Davies, J Jaroszewicz, J Li, L Martin-Carbonero, L Stabinski, Lars Henning, M Nyirenda, MA Thompson, Manuel Battegay, Marcel Tanner, Marian Hamisi, MC Kew, Omary Abdul, PM Bossuyt, R Weber, Ramadhani Ngwale, TEMS de Vries–Sluijs, TJ Nagu   +36 more
core   +4 more sources

Rapid diagnostic testing for malaria [PDF]

Tropical Medicine & International Health, 2003
SummaryMalaria rapid diagnostic devices (MRDD) have been developed with the hope that they would offer accurate, reliable, rapid, cheap and easily available alternatives to traditional methods of malaria diagnosis. The results from early malaria rapid diagnostic studies were quite promising, especially for detecting Plasmodium falciparum at densities ...
Clinton K, Murray, David, Bell, Robert A, Gasser, Chansuda, Wongsrichanalai   +3 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source