Results 131 to 140 of about 554,532 (299)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Magnetohydrodynamical origin of eclipsing time variations in post-common-envelope binaries for solar mass secondaries

, 2019
| openaire: EC/H2020/665667/EU//EPFL FellowsEclipsing time variations have been observed for a wide range of binary systems, including post-common-envelope binaries. A frequently proposed explanation, apart from the possibility of having a third body, is
Völschow, Marcel, Schleicher, Dominik R. G., Navarrete, Felipe H., Navarrete, Felipe H, Käpylä, Petri J, Mennickent, Ronald E, Käpylä, Petri J., Schober, Jennifer, Voelschow, Marcel, Schleicher, Dominik R G, Kaepylae, Petri J., Mennickent, Ronald E.   +11 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Variations in Atlantic surface ocean paleoceanography, 50°-80°N: A time-slice record of the last 30,000 years

, 1995
Eight time slices of surface-water paleoceanography were reconstructed from stable isotope and paleotemperature data to evaluate late Quaternary changes in density, current directions, and sea-ice cover in the Nordic Seas and NE Atlantic.
Erlenkeuser, Helmut, Michael Sarnthein, Schulz, Hartmut, Jung, S, Johannessen, Gro, Mara Weinelt, Samthein, Michael, Eystein Jansen, Duplessy, Jean Claude, Truls Johannessen, Flatoy, A, Hartmut Schulz, Labeyrie, Laurent, Jansen, E, Sarnthein, Michael, Sarnthein, M, Jean Claude Duplessy, Schulz, H, Labeyrie, L, Maslin, M, Uwe Pflaumann, Pflaumann, U, Jansen, Eystein, Sarntheim, Michael, Pflaumann, Uwe, Arnold, Maurice, Arnold, M, Nalan Koc, Weinelt, Mara, Duplessy, Jean, Koc, Nalan, Duplessy, JC, Koc, N, Simon Jung, Weinelt, M, Erlenkeuser, H, Helmut Erlenkeuser, Jung, Simon, Laurent Labeyrie, Johannessen, T, Astrid Flatøy, Gro Johannessen, Flat0y, Astrid, Maslin, Mark, Mark Maslin, Maurice Arnold, Flatøy, Astrid, Johannessen, G, Johannessen, Truls   +48 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impact of Power Fluctuations on Voltage Variations for Remote Distribution Networks with High PV Penetrations

, 2018
With the rapid development of photovoltaic (PV) technology, more and more utility-scale PV plants are established in remote areas due to abundant and low-priced land. However, these remote areas are usually connected to zone substations through long weak
Tapan Kumar Saha, Bai, Feifei, Ruifeng Yan, Feifei Bai, Saha, Tapan Kumar, Yan, Ruifeng   +5 more
core   +1 more source

Fine-tuning coexistence: Wildlife's short-term responses to dynamic human disturbance patterns

Global Ecology and Conservation
Anthropogenic disturbance elicits adaptive responses in wildlife, generally aimed at risk-avoidance, ultimately imposing constraints on their spatial and temporal niches.
Davide Mirante, Leonardo Ancillotto, Andrea Zampetti, Giuseppe Coiro, Gianfranco Pisa, Cristina Santocchi, Matteo Giuliani, Luca Santini   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Sub-second variations of high energy ( 300 keV) hard X-ray emission from solar flares

, 1986
Subsecond variations of hard X-ray emission from solar flares were first observed with a balloon-borne detector. With the launch of the Solar Maximum Mission (SMM), it is now well known that subsecond variations of hard X-ray emission occur quite ...
Bai, Taeil
core  

Electromagnetic Radiation From Temporal Variations in Space-Time and Progenitors of Gamma Ray Burst and Millisecond Pulsars

, 2007
A time varying space–time metric is shown to be a source of electromagnetic radiation even in the absence of charge sources. The post-Newtonian approximation is used as a realistic model of the connection between the space–time metric and a time-varying ...
Jones, Preston
core   +1 more source