Family quality‐of‐life burden in chronic spontaneous urticaria: A multicentre study
Poor control of chronic spontaneous urticaria (CSU) significantly worsens family members' quality of life, especially in emotional, physical, and social domains. Higher disease severity was linked to increased caregiving burden and household expenditures, highlighting the need for family‐centred CSU care and support across diverse global populations ...
Beatrice Martinez Zugaib Abdalla +33 more
wiley +1 more source
DDX17-mediated raptor-dependent mTORC1 activation links autophagy inhibition and metabolic compensation in HCC development. [PDF]
Lv C +9 more
europepmc +1 more source
West Nile virus detected in louse flies (Diptera: Hippoboscidae) collected from rehabilitated raptors in South Carolina. [PDF]
Brown KM +8 more
europepmc +1 more source
Long‐term efficacy of abrocitinib in patients with moderate‐to‐severe atopic dermatitis to 2 years
JADE EXTEND is an ongoing phase 3, long‐term extension study of previous abrocitinib trials. Patients were adults and adolescents ≥12 years with moderate‐to‐severe atopic dermatitis. Long‐term abrocitinib treatment resulted in clinically meaningful outcomes and improvements in patient‐reported outcomes up to Week 112 in patients with moderate‐to‐severe
Melinda J. Gooderham +14 more
wiley +1 more source
Rhizoma Dioscoreae Nipponicae attenuates airway remodeling and angiogenesis-related changes in asthma with altered mTOR/4EBP1/HIF-1α/VEGF pathway markers. [PDF]
Zhou X, Wang Z, Zheng S.
europepmc +1 more source
Durability of response to icotrokinra for high‐impact site psoriasis: 1‐year ICONIC‐TOTAL findings
Participants with at least moderate scalp, genital or hand/foot psoriasis receiving once‐daily oral icotrokinra achieved high, durable rates of overall and high‐impact site psoriasis clearance, showed substantial nail psoriasis improvement and exhibited no safety signals through 1 year, supporting icotrokinra use for long‐term management of high‐impact
Richard B. Warren +15 more
wiley +1 more source
Treatment‐associated phenotype switching between psoriasis and atopic dermatitis
This international, multicentre real‐world study of 148 patients’ documents treatment‐associated, bidirectional phenotype switching between psoriasis and atopic dermatitis. Psoriasis‐to‐eczematous switches occurred predominantly with IL‐17 and IL‐23 inhibitors, whereas AD‐to‐psoriasiform switches occurred exclusively during treatment with biologic ...
Tiago Torres +28 more
wiley +1 more source
HSP27 functional switch drives castration-resistant prostate cancer via mTOR pathway activation, highlighting promising combination therapies. [PDF]
Duong QH +15 more
europepmc +1 more source
Cumulative isotretinoin dosing, treatment response and acne relapse: A randomized controlled trial
In this randomized controlled trial, cumulative isotretinoin doses of 120 and 150 mg/kg showed similar relapse rates at 12 months. Both regimens achieved substantial and comparable reductions in inflammatory acne lesions across the face, chest and back.
Ruggero Cascio Ingurgio +16 more
wiley +1 more source
Endangered Steppe Eagle (<i>Aquila nipalensis</i>) (Aves, Accipitriformes, Accipitridae) genome and mitogenome assembly: A resource for molecular evolution and comparative genomics. [PDF]
Buthasane W +10 more
europepmc +1 more source

