Results 211 to 220 of about 21,750 (299)

Gene-Silencing Therapeutic Approaches Targeting PI3K/Akt/mTOR Signaling in Degenerative Intervertebral Disk Cells: An In Vitro Comparative Study Between RNA Interference and CRISPR-Cas9. [PDF]

Cells
Ryu M, Yurube T, Takeoka Y, Kanda Y, Tsujimoto T, Miyazaki K, Ohnishi H, Matsuo T, Kumagai N, Kuroshima K, Hiranaka Y, Kuroda R, Kakutani K.   +12 more
europepmc   +1 more source

Th2 mRNA gene expression analysis separates Prurigo nodularis into two immune signature groups

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 10, Page 1750-1759, October 2025.
Protein expression, histology and RNA analyses were performed from patients with prurigo nodularis (PN). All patients had typical PN characteristics. Lymphocytes/monocytes demonstrated more frequent positive staining signals in lesional versus non‐lesional samples for IL‐31, IL‐31RA, OSM and OSMRb.
Sonja Ständer, Emma Guttman‐Yassky, Gil Yosipovitch, Henning Wiegmann, Dieter Metze, Madeline Kim, Ester Del Duca, Kent Bondensgaard, John F. Paolini, on behalf of The LOTUS‐PN Investigators Group, David Pariser, Gil Yosipovitch, Adam Friedman, Timothy Berger, Brian Kim, Jonathan Silverberg, Maria Alora‐Palli, Swarna Ekanayake‐Bohlig, Sonja Ständer, Jacek Szepietowski, Elke Weisshaar   +20 more
wiley   +1 more source

Tiny Messengers, Huge Consequences: Extracellular Vesicles and mTOR Signaling in Neuroinflammation

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Neuroinflammation is a crucial mediator in the pathogenesis of multiple neurodegenerative diseases, acting not only as a consequence but also as a driver of disease progression. Yet, much remains to be understood about the molecular and cellular events involved.
P. Garcia‐Segura, A. Chicote‐González, A. Espasa‐Marco, M. Garcia‐Alcaraz, L. Mora‐Bernabé, M. Abelló‐Fernández, C. Malagelada   +6 more
wiley   +1 more source

Thyroid hormones inhibit tumor progression and enhance the antitumor activity of lenvatinib in hepatocellular carcinoma via reprogramming glucose metabolism. [PDF]

Cell Death Discov
Yang CC, Yan YC, Pan GQ, Meng GX, Zhang X, Yan LJ, Ding ZN, Wang DX, Li RZ, Li GZ, Dong ZR, Li T.   +11 more
europepmc   +1 more source

Intrinsic and Extrinsic Factors Simultaneously Modulated the Use of Roadways by Golden Eagles During Winter. [PDF]

Ecol Evol
Layfield JF, Bedrosian B, Chalfoun A, Domenech R, Lewis SB, Smith BW, Merkle JA.   +6 more
europepmc   +1 more source

TSC2-mTORC1 axis regulates morphogenesis and neurological function of Gli1⁺ adult-born dentate granule cells. [PDF]

Mol Biol Cell
Kowalczyk M, Lee YJ, Huang WH.
europepmc   +1 more source

Utility of Cross-species Amplification among Raptors

, 2004
Hideyuki Ito, Akiko YAMAJI, Motoko Abe, Tetsuma MURASE, Toshio Tsubota   +4 more
openalex   +2 more sources

The Role of Aging in Heart Failure With Preserved Ejection Fraction: Focus on Proteostatic Imbalance. [PDF]

JACC Basic Transl Sci
Salzano A, Cittadini A.
europepmc   +1 more source

Tspo Depletion Exacerbates Steatosis Through Fatty Acid Uptake. [PDF]

J Cell Mol Med
Li Y, Chen L, Sottas C, Patel ND, Raul MC, Papadopoulos V.   +5 more
europepmc   +1 more source