Results 221 to 230 of about 45,664 (353)

Intratumoral vidutolimod as monotherapy or in combination with pembrolizumab in patients with programmed cell death 1 blockade–resistant melanoma: Final analysis from a phase 1b study

open access: yesCancer, Volume 131, Issue 15, 1 August 2025.
Abstract Background New treatment options are needed for patients with metastatic anti–programmed cell death 1 (PD‐1)–resistant melanoma. The final analysis of a phase 1b study evaluating the Toll‐like receptor 9 agonist vidutolimod is reported here. Methods This two‐part, open‐label, multicenter, phase 1b study in adults with metastatic/unresectable ...
Mohammed M. Milhem   +22 more
wiley   +1 more source

Rapid and Effective Determination of Ethyl Glucuronide in Hair by Micro Extraction by Packed Sorbent (MEPS) and LC‐MS/MS

open access: yesDrug Testing and Analysis, Volume 17, Issue 8, Page 1160-1166, August 2025.
The development and validation of a MEPS method for the purification of hair extract for the EtG determination and quantification in the keratin matrix is the main focus of this study. The method is fast and effective and, as a miniaturised technique, requires only small amounts of solvent.
Sara Odoardi   +4 more
wiley   +1 more source

Spatial analysis of vehicular trauma and identification of hotspots in North Carolina chelonians

open access: yesThe Journal of Wildlife Management, Volume 89, Issue 6, August 2025.
Vehicular trauma is a leading cause of morbidity and mortality in chelonians admitted to the Turtle Rescue Team at North Carolina State University. This study used 15 years of retrospective data on turtle‐vehicular collisions to examine geospatial factors linked to vehicular mortality.
Aswini Cherukuri   +2 more
wiley   +1 more source

Appendix I List of Species of Raptor [PDF]

open access: bronze, 2002
FRCPath John E. Cooper DTVM
openalex   +1 more source

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

open access: yesMedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang   +10 more
wiley   +1 more source

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