Results 51 to 60 of about 25,895 (257)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Nitrite complexes of the rare earth elements [PDF]

Dalton Trans., 2014
The coordination chemistry of the nitrite anion has been investigated with rare earth elements, and the resulting complexes were structurally characterized. Among them, the first homoleptic examples of nitrite complexes of samarium, ytterbium and yttrium are described.
Pouessel, Jacky, Thuéry, Pierre, Berthet, Jean-Claude, Cantat, Thibault   +3 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Rare Earth Element Contents and Occurrence Forms in Weathering Crust Ion Adsorption Rare Earth Ore

Yankuang ceshi
The weathering crust ion adsorption type rare earth deposit has the characteristics of complete REE types, low radioactivity, high heavy rare earth contents, and easy mining, making it an extremely important type of rare earth deposit.
Xilian XIAO, Min GUO, Xin SHAO, Juanjuan TAN, Lei WANG, Xiaofei QIU   +5 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Coal ash resources and potential for rare earth element production in the United States

International Journal of Coal Science & Technology
The renewable energy industry is heavily reliant on rare earth elements, underscoring the need to develop resources and production. The objective of this work was to estimate coal ash resources and potential for extraction of rare earth elements using ...
Robert C. Reedy, Bridget R. Scanlon, Davin A. Bagdonas, James C. Hower, Dennis James, J. Richard Kyle, Kristine Uhlman   +6 more
doaj   +1 more source

Rare earth element dynamics in the deep subsurface of a high-energy beach

Frontiers in Marine Science
Subterranean estuaries of high-energy beaches are considered as dynamic biogeochemical reactors. The advective porewater flow and associated transport of organic and inorganic constituents reach deep into the subsurface.
Magali Roberts, Anja Reckhardt, Kojo Amoako, Grace A. Abarike, Hannelore Waska, Jutta Niggemann, Felix Auer, Moritz Holtappels, Michael Ernst Böttcher, Michael Ernst Böttcher, Michael Ernst Böttcher, Katharina Pahnke   +11 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Evaluation on Delineation Methods for Ion-adsorption Type Rare Earth Ore Body

Yankuang ceshi, 2013
Ion-adsorption type rare earth ore is unique and a valuable resource in China. Total rare earth oxides (SREO) and leaching quantities of rare earth oxides (SREO) are important indices of evaluation of the scope and value of rare earth resources.
DENG Mao-chun, WANG Deng-hong, ZENG Zai-lin, ZHANG Yong-zhong, ZHAO Zhi, ZOU Xin-yong, CHEN Bin-feng   +6 more
doaj  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source