Results 121 to 130 of about 3,197 (223)

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló   +2 more
wiley   +1 more source

Att spegla världen? En kvalitativ textanalys av litteraturhistoriska svenskläroböcker efter Gy2011 [PDF]

open access: yes, 2017
Syftet är att utifrån postkolonial teoribildning synliggöra de föreställningar om Västerlandet och Österlandet som återfinns i litteraturhistoriska läroböcker för gymnasiets svenskämne.
Lindström, Anton
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Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

open access: yesAdvanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong   +13 more
wiley   +1 more source

”Vi kallar dem för gatubarn” En kritisk diskursanalys av medierapporteringen om ungdomarna i Nordstan. [PDF]

open access: yes, 2017
Title: “The kids of the street”- a discourse analysis about the reporting of the young people in Nordstan. Author: Nanna Nilsson, Hanna Dahlström och Johanna Sundquist Subject: Undergraduate research paper in Journalism studies, Dept.
Dahlström, Hanna   +2 more
core  

Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

open access: yesAdvanced Science, EarlyView.
Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go   +12 more
wiley   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

open access: yesAdvanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang   +14 more
wiley   +1 more source

Plan mot kränkande behandling - med särskild fokus på nätmobbning [PDF]

open access: yes, 2011
I samhället idag finns det en ökad tillgänglighet och användning av internet. Nätmobbning har därför blivit allt vanligare och är ett problem som är svårt att komma åt.
Gyllensten, Natalie
core  

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao   +11 more
wiley   +1 more source

CONSIDERATIONS ON THE EXISTENCE OF DISCRIMINATION IN GRANTING THE STATE PENSIONS [PDF]

open access: yes, 2012
Social protection is a way that respects human dignity. This is because each citizen is a part of society and he contributes to its development. In return, the society gives to him a social protection, materialized in social services including the ...
MĂDĂLINA TOMESCU
core  

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