Results 151 to 160 of about 6,418,597 (300)
Novel Insight into the Concept of Favorable Combination of Electrodes in High Voltage Supercapacitors: Toward Ultrahigh Volumetric Energy Density and Outstanding Rate Capability. [PDF]
Glob Chall, 2022 Elsa G +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Mapping sustainable development in a capability perspective [PDF]
The importance of the notion of sustainable development has been advocated, among others, by Amartya Sen. In Sen’s view it is necessary to depart from the general strategy of defining sustainable development only in terms of fulfilment of needs and to ...
Enzo Di Giulio, Marco Grasso
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Measuring Regional Innovative Capability [PDF]
Regional innovation environment has experienced remarkable changes in the recent decades. Innovativeness at regional level is seen as a consequence of networked co-operation in a regional innovation system, which sets demands for new kinds of regional ...
Vesa Harmaakorpi, Tomi Tura
core
Free-Standing rGO-CNT Nanocomposites with Excellent Rate Capability and Cycling Stability for Na2SO4 Aqueous Electrolyte Supercapacitors. [PDF]
Nanomaterials (Basel), 2021 Du X, Qin Z, Li Z.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source