Results 81 to 90 of about 6,418,597 (300)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
InfoMatThe slow kinetics and irreversibility of Li2S deposition and dissolution during the sulfur reduction/evolution reactions (SRR/SER) hinder the fast‐charging and high‐rate capabilities of lithium–sulfur (Li/S) batteries.
Lei Ji +9 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Desirability to characterize process capability [PDF]
Over the past few years continuously new process capability indices have been developed, most of them with the aim to add some feature missed in former process capability indices.
Weihs, Claus, Jessenberger, J.
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
IT DYNAMIC CAPABILITY DEVELOPMENT IN THE CONTEXT OF DATA GENESIS CAPABILITY [PDF]
Dynamic Capabilities are often considered as the factor justifying the different degrees of success of organizations in turbulent environment. However Dynamic Capability development remains a difficult issue to research, with a paucity of work directly ...
Claudio Vitari
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Overview of Capability-Driven Development Methodology
, 2018 The Capability-Driven Development (CDD) methodology supports development, delivery, and management of organization and information system capabilities.
Stirna, Janis, +2 more
core +1 more source
Investigating the Electrochemical Characteristics of Lithium Vanadium Phosphate Cathode Synthesized by the Solution Combustion Method Utilizing Cetyltrimethylammonium Bromide as a Fuel for Lithium-Ion Batteries Applications [PDF]
Journal of Advanced Materials in EngineeringIntroduction and Objectives: Optimization of vanadium phosphate compounds through the control of synthesis methods plays a key role in enhancing their performance. In this research, the effect of adding cetyltrimethylammonium bromide with different molar
Mohammad Tahernejad Javazm +2 more
doaj +1 more source