Results 41 to 50 of about 248,354 (262)
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
PharmaceuticsBackground: Topical statin therapy holds promise for ocular diseases, such as age-related macular degeneration, but the effective delivery to the posterior segment is limited by poor aqueous solubility, chemical instability, and ocular barriers ...
Ismael Abo Horan +2 more
doaj +1 more source
Atmosphere, 2022 Carbazole is one of the typical heterocyclic aromatic compounds (NSO-HETs) observed in polluted urban atmosphere, which has become a serious environmental concern.
Zhuochao Teng +9 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Revealing Hydrogen States in Carbon Structures by Analyzing the Thermal Desorption Spectra
C, 2022 An effective methodology for the detailed analysis of thermal desorption spectra (TDS) of hydrogen in carbon structures at micro- and nanoscale was further developed and applied for a number of TDS data of one heating rate, in particular, for graphite ...
Yury S. Nechaev +6 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Toxics, 2023 Metronidazole (MNZ), a typical example of nitroimidazole antibiotics, is widely used in the treatment of infectious diseases caused by anaerobic bacteria.
Jingyu Sun, Ruijun Chu, Zia Ul Haq Khan
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Green Leaf Volatiles in the Atmosphere—Properties, Transformation, and Significance
Atmosphere, 2021 This review thoroughly covers the research on green leaf volatiles (GLV) in the context of atmospheric chemistry. It briefly takes on the GLV sources, in-plant synthesis, and emission inventory data.
Kumar Sarang +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source