Results 81 to 90 of about 4,680,033 (195)

Network-assisted optimal rate control methods in cognitive networks

Tongxin xuebao, 2013
Orienting the multi-rate cognitive networks,overcoming the typical characteristics of dynamics to implement the autonomy and rationality of rate control,first the rate control framework based on the presented improved IEEE 1900.4 architecture was ...
Chun-gang YANG, Min SHENG, Yan-jie DONG, Jian-dong LI, Hong-yan LI, Qin LIU   +5 more
doaj  

New Insights into Rate Control: Time in Target Range of Resting Heart Rate and Major Adverse Outcomes in Atrial Fibrillation

Global Heart
Background: Few studies have examined the relationship between the fluctuation of heart rate control over time and cardiovascular outcomes in patients with atrial fibrillation.
Yuhui Lai, Xingfeng Xu, Shaozhao Zhang, Rihua Huang, Yiquan Huang, Xiangbin Zhong, Zhenyu Xiong, Yifen Lin, Huimin Zhou, Yue Guo, Xinxue Liao, Yuedong Ma, Xiaodong Zhuang   +12 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

One‐year outcomes of rate versus rhythm control of atrial fibrillation in the Kerala‐AF Registry

Journal of Arrhythmia
Background There is ongoing debate around rate versus rhythm control strategies for managing atrial fibrillation (AF), however, much of the data comes from Western cohorts.
Peter Calvert, Yang Chen, Ying Gue, Dhiraj Gupta, Jinbert Lordson Azariah, A. George Koshy, Geevar Zachariah, Gregory Y. H. Lip, Bahuleyan Charantharayil Gopalan, the Kerala AF Registry Investigators   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Comparative Effectiveness of Adenosine, Diltiazem, and Metoprolol in Rate Control of Supraventricular Tachyarrhythmias in Geriatric Patients: A Retrospective Cohort Study

Global Emergency and Critical Care
Objective: To evaluate the comparative effectiveness of adenosine, diltiazem, and metoprolol in achieving rate control in geriatric patients presenting with supraventricular tachyarrhythmia (SVT) and to identify clinical predictors associated with ...
Gökhan Eyüpoğlu, Mehmet Tatlı, Ebru Akkoç, Ezgi Zengin   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source