Results 181 to 190 of about 1,348,142 (299)

Density Dependence During Evolutionary Rescue Increases Extinction Risk but Does Not Prevent Adaptation. [PDF]

Ecol Lett
Olazcuaga L, Melbourne BA, Nordstrom SW, Hufbauer RA.   +3 more
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Medical Student Attitudes Toward Advanced Practice Provider Independence Legislation. [PDF]

J Am Board Fam Med
Bohler F, Aggarwal ND, Simon CA, Burmeister JR, Taranikanti V.   +4 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Clinical Outcomes and Patient Satisfaction of an Enhanced Depth of Focus Intraocular Lens Targeted for Mini-Monovision

Clinical Ophthalmology
Nuno Campos1,2 1Hospital Garcia de Orta, Almada, Portugal; 2Hospital CUF TEJO, Lisboa, PortugalCorrespondence: Nuno Campos, Ophthalmology Department, Hospital Garcia de Orta, Almada, Portugal, Email nunocampos.dr@gmail.comPurpose: To assess the clinical ...
Campos N
doaj  

RL-Based Parallel LDPC Decoding with Clustered Scheduling. [PDF]

Entropy (Basel)
Ozkan Y, Yakimenka Y, Kliewer J.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Brain Is the Rate-Limiting Organ of Longevity: A Brain-First Systems Framework for Aging. [PDF]

Cureus
Lakhan SE.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Simultaneous kidney and pancreas transplantation: Current trends and challenges. [PDF]

World J Transplant
Alquadan KF, Belal AA, Mehta R, Leghrouz M, Ibrahim H, Vrakas G, Santos AH.   +6 more
europepmc   +1 more source