Results 101 to 110 of about 166,352,380 (305)
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Real convergence and regime-switching among EU accession countries [PDF]
, 2008 Real convergence among the ten EU 2004 accession economies is investigated with respect to long-run real interest parity. We employ a novel approach where unit-root tests for real interest differentials are embedded within a Markov regime-switching ...
Holmes, Mark J. +3 more
core +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
On the Rate of Moment Convergence for a Normalized Random Walk
, 2012 [[abstract]]In this paper, we study the convergence rate of the r-th moments of a normalized simple random walk. When r = 1, we use the discrete-time version of Ito-Tanaka formula to obtain an exact convergence rate.
Cheng, Tsung-Lin; Chow, Yuan-Shih; Yan, Yung-Lu
core
Rates of convergence for the maximum likelihood estimator in the convolution model [PDF]
Opuscula Mathematica, 2006 Rates of convergence for the maximum likelihood estimator in the convolution model, obtained recently by S. van de Geer, are reconsidered and corrected.
Piotr Majerski
doaj
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
A Note on the Rate of Convergence of the Bootstrap
Journal of Approximation Theory, 1993 Suppose \((X_ i)_{i\in\mathbb{N}}\) is an i.i.d. sequence of random variables defined on some probability space \((\Omega,{\mathcal A},\mathbb{P})\) with distribution function (d.f.) \(F\), \(F_{\eta_ n}\) denotes the d.f. of the standardized sample mean \(\eta_ n=\Bigl(\sum^ n_{i=1} X_ i- \mu_ n\Bigr)/(\sigma n^{1/2})\), \(\mu=\mathbb{E}(X_ 1)\) the ...
openaire +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source