Results 111 to 120 of about 173,711,968 (308)
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Rates of convergence for the maximum likelihood estimator in the convolution model [PDF]
Opuscula Mathematica, 2006 Rates of convergence for the maximum likelihood estimator in the convolution model, obtained recently by S. van de Geer, are reconsidered and corrected.
Piotr Majerski
doaj
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
The Maastricht Criteria and the Euro. Has the Convergence Continued? [PDF]
We analyze the performance of the Maastricht convergence criteria (inflation, long-term interest rate, annual and overall public debt) of the European Monetary Union (EMU) that led to the introduction of the Euro on Jan.
Polasek, Wolfgang, Amplatz, Christian
core
Least squares estimation of regression coefficients of singular random fields observed on a sphere [PDF]
, 2001 We present some results on the rate of convergence to the normal law of the least square estimates of the regression coefficient of random fields with long range dependence observed on a ...
Anh, Vo +5 more
core
A Note on the Rate of Convergence of the Bootstrap
Journal of Approximation Theory, 1993 Suppose \((X_ i)_{i\in\mathbb{N}}\) is an i.i.d. sequence of random variables defined on some probability space \((\Omega,{\mathcal A},\mathbb{P})\) with distribution function (d.f.) \(F\), \(F_{\eta_ n}\) denotes the d.f. of the standardized sample mean \(\eta_ n=\Bigl(\sum^ n_{i=1} X_ i- \mu_ n\Bigr)/(\sigma n^{1/2})\), \(\mu=\mathbb{E}(X_ 1)\) the ...
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng +4 more
wiley +1 more source
NOMINAL CONVERGENCE: THE CASE OF ROMANIA [PDF]
The main objectives of this paper are: determining the extent to which the indicators of nominal convergence reflect the reality of the Romanian economy, in order to find an optimal correlation between nominal and real convergence from the point of view ...
Silvia Mărginean, Ramona Orăştean
core
Non-autonomous approximations governed by the fractional powers of damped wave operators
Electronic Journal of Differential Equations, 2019 In this article we study non-autonomous approximations governed by the fractional powers of damped wave operators of order $\alpha \in (0,1)$ subject to Dirichlet boundary conditions in an $n$-dimensional bounded domain with smooth boundary.
Marcelo J. D. Nascimento +1 more
doaj