Results 81 to 90 of about 552,445 (261)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Shoulder angle effects on neuromuscular activation and rapid force production: sEMG time–frequency and force–time analyses

Frontiers in Bioengineering and Biotechnology
IntroductionMaximal isometric shoulder force production constitutes an angle-dependent neuromuscular task; changes in shoulder elevation can meaningfully modify the relative contribution of glenohumeral and scapulothoracic musculature through concomitant
Salih Çabuk, Süleyman Ulupınar, İzzet İnce, Muhammet Raşit İnaç, Hasan Hüseyin Yılmaz, Osman Ateş, Cebrail Gençoğlu, Serhat Özbay, Zelal Apaydın   +8 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Development of a mechanism for adjusting force distribution rate in force sensors to implement variable admittance control

Nihon Kikai Gakkai ronbunshu
A novel force distribution adjustment mechanism for force sensors is proposed to implement variable admittance control in robotic systems. While admittance control is widely utilized in physical human–robot interactions (pHRI), existing approaches face ...
Shujiro SUGIYAMA, Toru TSUMUGIWA, Ryuichi YOKOGAWA   +2 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Common inputs to motor units are modulated by force profile and muscle length

Experimental Physiology
Groups of motor units receive common synaptic inputs from specialized networks of premotor neurons to produce movement. Here, we test whether common inputs received by motor units in the first dorsal interosseous are fixed or task‐dependent during ...
Abdulkerim Darendeli, Oscar Soto, Eugene Tunik, Mathew Yarossi   +3 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Does Test Duration Matter? Comparing 1‐s and 5‐s Isometric Mid‐Thigh Pull Protocols for Performance Diagnostics in Basketball Players

European Journal of Sport Science
To compare kinetic characteristics of a 1‐s isometric mid‐thigh pull (IMTP) protocol with the traditional 5‐s protocol and examine their associations with basketball‐specific performance.
Sumeng Xu, Hailong Yu, Tian Huang, Chuanzhi Wang, Longyan Yi, Bing Yan, Sulin Cheng, Xiuqiang Wang, Yang Wang, Olivier Girard   +9 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source