Results 81 to 90 of about 167,647,873 (306)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Isometric Mid-Thigh Pull Performance in Rugby Players: A Systematic Literature Review
Journal of Functional Morphology and Kinesiology, 2020 The isometric mid-thigh pull (IMTP) is a multi-joint test of whole-body force production relevant to rugby players. “Rugby AND (mid-thigh pull OR midthigh pull OR mid thigh pull” were searched in PubMed, Sportdiscus, Academic Search Premier, CINAHL Plus ...
Eric A. Martin, George K. Beckham
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Impact of Stiffness of Quadriceps on the Pedaling Rate of Maximal Cycling
LifePropulsive power is one of the factors that determine the performance of sprint cycling. Pedaling rate is related to power output, and stiffness is associated with improving performance in athletic tasks.
Loi Ieong, Xindi Ni, Huisong Xie, Ye Liu
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
BioengineeringPurpose: This study investigated the contribution of lower limb kinetics to punch performance in amateur boxing and examined the effects of fatigue on biomechanical efficiency.
Charles Stewart +5 more
doaj +1 more source
Faster movement speed results in greater tendon strain during the loaded squat exercise
Frontiers in Physiology, 2016 Introduction: Tendon dynamics influence movement performance and provides the stimulus for long-term tendon adaptation. As tendon strain increases with load magnitude and decreases with loading rate, changes in movement speed during exercise should ...
Jacob Edward Earp +5 more
doaj +1 more source
Development Effectiveness Overview (DEO) 2024
The Development Effectiveness Overview (DEO) is an annual report produced by the IDB Group to share the results and impact of its work in Latin America and the Caribbean.
Inter-American Development Bank
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The IDB: Vol. 17, no. 3, March 1990
, 1990 The IDB reports on economic and social development trends in Latin America and the Caribbean and on the activities of the Bank.
Inter-American Development Bank
core +1 more source