Results 111 to 120 of about 912,950 (301)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Modelling rate of penetration in drilling operations using RBF, MLP, LSSVM, and DT models. [PDF]

Sci Rep, 2022
Riazi M, Mehrjoo H, Nakhaei R, Jalalifar H, Shateri M, Riazi M, Ostadhassan M, Hemmati-Sarapardeh A.   +7 more
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Regression Models and Fuzzy Logic Prediction of TBM Penetration Rate

Open Engineering, 2017
This paper presents statistical analyses of rock engineering properties and the measured penetration rate of tunnel boring machine (TBM) based on the data of an actual project.
Minh Vu Trieu, Katushin Dmitri, Antonov Maksim, Veinthal Renno   +3 more
doaj   +1 more source

The rate of penetration of liquid into tablets.

Chemical and Pharmaceutical Bulletin, 1981
A direct measuring method for the liquid penetration rate into tablets was devised and compared with the usual powder method. The effect of the diameter and shape of tablets on the penetration rate was examined by using a two-dimensional model and confirmed to be negligible in practice.
E, Fukuoka, S, Kimura, M, Yamazaki
openaire   +3 more sources

Preliminary study of gaseous nitrogen-liquid oxygen mixing and self cleaning [PDF]

The penetration of gaseous nitrogen into liquid oxygen at a pressure of 150 psi was determined by monitoring the composition of the evaporating liquid in a nitrogen analyzer.
Zuckerwar, A. J.
core   +1 more source

Muon-spin-relaxation study of the magnetic penetration depth in MgB2

, 2001
The magnetic vortex lattice (VL) of polycrystalline MgB2 has been investigated by transverse-field muon-spin-relaxation (TF-MuSR). The evolution of TF-MuSR depolarization rate, sigma, that is proportional to the second moment of the field distribution of
A. Amato, A.M. Mulders, A.Y. Liu, B. Mühlschlegel, B. Pümpin, C. Bernhard, C. Panagopoulos, Ch. Niedermayer, Ch. Niedermayer, Ch. Walti, D. Harshman, D.G. Hinks, E.H. Brandt, F. Bouquet, G. Karapetrov, H. Kotegawa, J. Kortus, J. Nagamatsu, K. Ahn, M. Xu, O.F. de Lima, P.J. Hirschfeld, R. K. Kremer, R. Osborn, R.S. Hayano, S. Haas, S. Lee, S. Patnaik, S.L. Bud‘ko, T. Holden, T. Takahashi, T. Yildirim, W. Bardford, W.N. Hardy, X.K. Chen, Y. Wang   +35 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source