Results 111 to 120 of about 915,295 (349)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Modeling of Metal Penetration Rate by a High Power Continuous Wave Laser [PDF]

, 2012
Wan-Soon Shin, Hae-Seog Koh, Byung-Suh Park, Eung-Cheol Kang   +3 more
openalex   +1 more source

Investigating the Effects of Mechanical Properties of Rocks on Specific Energy and Penetration Rate of Borehole Drilling [PDF]

, 2020
Peter Kolapo
openalex   +1 more source

Modelling and Simulating Eulerian Venturi Effect of SBM to Increase the Rate of Penetration with Roller Cone Drilling Bit [PDF]

, 2023
Dennis Delali Kwesi Wayo, Sonny Irawan, Alfrendo Satyanaga, Ghulam Abbas   +3 more
openalex   +1 more source

An Advanced Long Short-Term Memory (LSTM) Neural Network Method for Predicting Rate of Penetration (ROP). [PDF]

ACS Omega, 2023
Ji H, Lou Y, Cheng S, Xie Z, Zhu L.
europepmc   +1 more source

Desiccation of a clay film: Cracking versus peeling

, 2008
Cracking and peeling of a layer of clay on desiccation has been simulated using a spring model. A vertical section through the layer with finite thickness is represented by a rectangular array of nodes connected by linear springs on a square lattice. The
Blaudeck, Peter, Dutta, Tapati, Hoffmann, K. H., Prehl, Janett, Sadhukhan, Supti, Tarafdar, Sujata   +5 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Regression Models and Fuzzy Logic Prediction of TBM Penetration Rate

Open Engineering, 2017
This paper presents statistical analyses of rock engineering properties and the measured penetration rate of tunnel boring machine (TBM) based on the data of an actual project.
Minh Vu Trieu, Katushin Dmitri, Antonov Maksim, Veinthal Renno   +3 more
doaj   +1 more source

Modelling rate of penetration in drilling operations using RBF, MLP, LSSVM, and DT models. [PDF]

Sci Rep, 2022
Riazi M, Mehrjoo H, Nakhaei R, Jalalifar H, Shateri M, Riazi M, Ostadhassan M, Hemmati-Sarapardeh A.   +7 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source