Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
When AAA Means B: The State of Credit Rating in India [PDF]
As in many other countries, India five year old credit rating industry has grown rapidly amidst persistent doubts about the quality of the rating service. This paper evaluates the ratings given by India leading credit rating agency, CRISIL.
Varma, Jayanth R., Ragunathan V
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From free association to free parameters: machine-learning empowers artificial intelligence models to rate the affective-relational aspects of narratives like an expert psychologist. [PDF]
Front Digit HealthSiefert CJ +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Rating Assignments: Lessons from International Banks [PDF]
This paper estimates ordered logit and probit regression models for bank ratings which also include a country index to capture country-specific variation.
Guglielmo Maria Caporale +2 more
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External validation of a machine learning-based web application for personalized testing of objective functioning using the five-repetition sit-to-stand test. [PDF]
Acta Neurochir (Wien)Arockia K +9 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Evaluation and Ranking for Scientific, Transparent and Applicable of Chinese Geriatrics Guidelines and Consensus Published in 2023. [PDF]
Aging Med (Milton)Li D +6 more
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
La metodología de rating “through the cycle”: aplicación para la estimación de ratings soberanos [PDF]
This paper analyses the through-the-cycle rating concept; basically, we try to specify its main characteristics, focusing on the differences with point-in-time ratings.
Pena, Alejandro, Rodríguez, Analía
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