Results 121 to 130 of about 327,754 (303)
Evaluation of the utility of sediment data in NASQAN (National Stream Quality Accounting Network) [PDF]
, 1983 Monthly suspended sediment discharge measurements, made by the USGS as part of the National Stream Quality Accounting Network (NASQAN), are analysed to assess the adequacy in terms of spatial coverage, temporal sampling frequency, accuracy of ...
Brooks, Norman H. +3 more
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Water flow measurements in Turkey's rivers and evaluation of alternative methods
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2013 The accuracy and sustainability in the flow measurement of rivers has a great importance for the water management, planning of water storage structures and prediction of floods.
Ramazan Meral, Ahmet Benli
doaj +1 more source
Tracking the affective state of unseen persons. [PDF]
, 2019 Emotion recognition is an essential human ability critical for social functioning. It is widely assumed that identifying facial expression is the key to this, and models of emotion recognition have mainly focused on facial and bodily features in static ...
Chen, Zhimin, Whitney, David
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
An analytical approach for predicting pilot induced oscillations [PDF]
, 1981 The optimal control model (OCM) of the human pilot is applied to the study of aircraft handling qualities. Attention is focused primarily on longitudinal tasks.
Hess, R. A.
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Uncertainty in river discharge observations: a quantitative analysis [PDF]
Hydrology and Earth System Sciences, 2009 This study proposes a framework for analysing and quantifying the uncertainty of river flow data. Such uncertainty is often considered to be negligible with respect to other approximations affecting hydrological studies.
G. Di Baldassarre, A. Montanari
doaj