Results 51 to 60 of about 452,911 (267)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Behavioural Assessment of the Dysexecutive Syndrome (BADS) no contexto do envelhecimento normal e patológico

Revista Brasileira de Geriatria e Gerontologia
Vários autores advogam a necessidade de avaliar o funcionamento executivo como um determinante robusto do estado funcional do indivíduo e como potencial marcador de demência.
Mariana Monteiro, Bruno Peixoto
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

International versions of the Menopause Rating Scale (MRS)

Health and Quality of Life Outcomes, 2003
Background Symptom scales for aging women have clinically been used for years and the interest in measuring health-related quality of life (HRQoL) has increased in recent years.
Schneider Hermann PG, Potthoff Peter, Heinemann Lothar AJ   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Reliability and validity analysis of the Menopause Rating Scale(MRS) Chinese version of the perimenopausal rating scale

Huli yanjiu, 2018
Objective:To measure the reliability and validity of Chinese version of Menopause Rating Scale.Methods:A total of 126 cases of perimenopausal women were evaluated by using MRS,and the results were analyzed on the reliability and validity.Results:The ...
Huang Lin, Liu Qin, Liu Yue
doaj  

Machine learning algorithm‐based estimation model for the severity of depression assessed using Montgomery‐Asberg depression rating scale

Neuropsychopharmacology Reports
Aim Depressive disorder is often evaluated using established rating scales. However, consistent data collection with these scales requires trained professionals.
Masanori Shimamoto, Kanako Ishizuka, Kento Ohtani, Toshiya Inada, Maeri Yamamoto, Masako Tachibana, Hiroki Kimura, Yusuke Sakai, Kazuhiro Kobayashi, Norio Ozaki, Masashi Ikeda   +10 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Adapting a self-efficacy scale to the task of teaching scientific reasoning: collecting evidence for its psychometric quality using Rasch measurement

Frontiers in Psychology
Besides teachers' professional knowledge, their self-efficacy is a crucial aspect in promoting students' scientific reasoning (SR). However, because no measurement instrument has yet been published that specifically refers to self-efficacy beliefs ...
Virginia Deborah Elaine Welter, Merryn Dawborn-Gundlach, Leroy Großmann, Moritz Krell   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source