Results 101 to 110 of about 13,076,781 (294)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Effects of cyclic loading on lateral bearing capacity of single pile in silty seabed
Yantu gongcheng xuebaoUnder larger wave loading, the bearing capacity of marine single pile foundation will be reduced, even instability occurs. A series of undrained shear triaxial tests on the remolded marine silt in Hangzhou Bay are carried out by means of the GDS triaxial
WANG Mingyuan 1, SUN Jizhu 2, WANG Yong 3, YANG Yang 4
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Claire, uma linda mulher, surfa em luta pelo amor: a prostituição em uma perspectiva cinematográfica
Revista Espaço Acadêmico, 2013 O objetivo do artigo é analisar a cultura e as representações difundidas em filmes que retratam a prostituta. Parte-se do pressuposto de que as referências sobre masculino e feminino, reproduzidas pelos meios de comunicação, no caso específico do cinema,
Francisca Ilnar Sousa
doaj
Disinflation in a DSGE Perspective: Sacrifice Ratio or Welfare Gain Ratio? [PDF]
When used to examine disinflation monetary policies, the current workhorse dynamic stochastic general equilibrium model of business cycle fluctuations is able to quantitatively account for the main stylized facts in terms of recessionary effects and ...
Guido Ascari, Tiziano Ropele
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
NOTAS SOBRE O ENSINO DE FILOSOFIA NOS CURSOS DE GRADUAÇÃO NO SERVIÇO SOCIAL
Cadernos Cajuína, 2019 Ministrar aulas de Filosofia exige esforço para lidar com uma diversidade de questões, como o conteúdo, a especificidade do lugar onde se ensinará e as especificidades do ensino de Filosofia.
Antonio Alex Pereira de Sousa
doaj
EJNMMI ResearchBackground Fibroblast activation protein (FAP) is an attractive target for cancer theranostics. Although FAP-targeted nuclear imaging demonstrated promising clinical results, only sub-optimal results are reported for targeted radionuclide therapy (TRT ...
Circe D. van der Heide +6 more
doaj +1 more source