Results 101 to 110 of about 369,033 (293)

Telescoping Density-Ratio Estimation

, 2020
Density-ratio estimation via classification is a cornerstone of unsupervised learning. It has provided the foundation for state-of-the-art methods in representation learning and generative modelling, with the number of use-cases continuing to proliferate.
Rhodes, Benjamin, Xu, Kai, Gutmann, Michael U.   +2 more
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An effective and economic estimation of population mean in stratified random sampling using a linear cost function

Heliyon
Improvement in the estimation of population mean has been an area of interest in sampling theory. So many estimators have been suggested for elevated estimation of the population mean in stratified random sampling, but there is still a gap for more ...
Abdullah A. Zaagan, Mukesh Kumar Verma, Ali M. Mahnashi, Subhash Kumar Yadav, Abdullah Ali H. Ahmadini, Mutum Zico Meetei, Rahul Varshney   +6 more
doaj   +1 more source

Neutrosophic Exponential Ratio-Type Estimator for Finite Population Mean [PDF]

Neutrosophic Sets and Systems
This paper proposes a neutrosophic exponential-type estimator for finite population mean estimation using auxiliary variables. Traditional statistical estimators often fall short when handling vague or uncertain data.
Anisha Taneja, Sachin Malik, Prem Shankar Jha   +2 more
doaj   +1 more source

Posterior Mean Super-Resolution with a Compound Gaussian Markov Random Field Prior

, 2012
This manuscript proposes a posterior mean (PM) super-resolution (SR) method with a compound Gaussian Markov random field (MRF) prior. SR is a technique to estimate a spatially high-resolution image from observed multiple low-resolution images. A compound
Inoue, Masato, Katsuki, Takayuki
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Neutrosophic Exponential Ratio-Type Estimator for Finite Population Mean in Stratified Sampling [PDF]

Neutrosophic Sets and Systems
This paper introduces an innovative neutrosophic exponential ratio-type estimator for estimating finite population means in stratified sampling environments with indeterminate data.
Anisha Taneja, Sachin Malik, Prem Shankar Jha   +2 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source