Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Improved Separate Ratio Exponential Estimator for Population Mean Using Auxiliary Information [PDF]
This paper advocates the improved separate ratio exponential estimator for population mean of the study variable y using the information based on auxiliary variable x in stratified random sampling. The bias and mean squared error (MSE) of the suggested
Yadav, Rochini +3 more
core
Appendix A. The derivation of age ratio estimator bias under aging error.
The derivation of age ratio estimator bias under aging ...
Paul B. Conn (143747) +2 more
core +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
An improved exponential ratio estimator for post-stratified sampling designs
This study proposes a new ratio-type exponential estimator for estimating the finite population mean under post-stratification. A simple random sample is first selected and later divided into post-strata using an auxiliary variable to improve the ...
Rizwan Yousuf +5 more
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
ON DIRECT KERNEL ESTIMATOR OF DENSITY RATIO
Estimation for a density ratio has an important role in statistical inference. We can use the estimator for testing homogeneity of two samples, detecting change point etc.
本山, 真誠 +5 more
core
Small Sample Bias Propreties of the System GMM Estimator in Dynamic Panel Data Models [PDF]
This paper examines analytically and experimentally why the system GMM estimator in dynamic panel data models is less biased than the first differencing or the level estimators even though the former uses more instruments.
Kazuhiko Hayakawa
core

