Results 71 to 80 of about 2,134,621 (300)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
State-captured Europeanisation. A Rational Choice Alternative [PDF]
Romanian Journal of European AffairsWhat is missing in our understanding of the stagnation and/or regression in the Europeanisation of the Western Balkan candidate countries? The current paper aims to present a conceptual novelty, coined as ‘state-captured Europeanisation’, which is based ...
Radu-Vladimir Răuță
doaj
Rational indecisive choice [PDF]
This paper proposes and characterises two preference-based choice rules that allow the decision maker to choose nothing if the criteria associated with them are satisfied by no feasible alternative.
Gerasimou, Georgios
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
RATIONAL CHOICE THEORY IN SOCIOLOGY: A METHODOLOGICAL ARGUMENT [PDF]
Revista Română de Sociologie, 2013 În the last years, rational choice theory (RCT) took over a lot of the social sciences, almost polarizing discussions in sociology, such that I was able to hear questions like: are there any other theories in sociology, besides rational choice theory ...
ALEXANDRA GHEONDEA-ELADI
doaj +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
The potentials and limitations of rational choice theory
Erasmus Journal for Philosophy and Economics, 2012 Gary S. Becker (Pennsylvania, 1930) is a university professor at the Departments of Economics, Sociology, and the Graduate School of Business at the University of Chicago, Illinois.
Catherine Herfeld
doaj +1 more source
Rational Choice: The Case of Path Dependent Procedures [PDF]
Describing a procedure in which choice proceeds in a sequence, we propose two alternatives ways of resolving the decision problem whenever the outcome is sequence-sensitive.
Bandyopadhyay, Taradas, Kunal Sengupta
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source