Results 81 to 90 of about 2,134,621 (300)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Bioethics and artificial intelligence: between deliberation on values and rational choice theory. [PDF]
Front Robot AI, 2023 Pinto-Bustamante BJ +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Corrigendum: Bioethics and artificial intelligence: between deliberation on values and rational choice theory. [PDF]
Front Robot AI, 2023 Pinto-Bustamante BJ +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Energy saving behavior in university organizations: The value of norm constructions in a "rational choice" action model. [PDF]
Front Psychol, 2023 Heib S, Hildebrand J, Kortsch T.
europepmc +1 more source
The computational complexity of boundedly rational choice behavior [PDF]
This research examines the computational complexity of two boundedly rational choice models that use multiple rationales to explain observed choice behavior.
Thomas DEMUYNCK
core
Rational theory choice: Arrow undermined, Kuhn vindicated [PDF]
, 2013 In a recent paper, Samir Okasha presented an argument that suggests that there is no rational way to choose among scientific theories. This would seriously undermine the view that science is a rational entreprise.
Bradley, Seamus
core
The Future of Rational Choice for Crime Prevention
, 2018 The rational choice perspective (RCP) is currently the core theoretical approach underpinning situational crime prevention (SCP). To date, many crimes have been studied through the lens of RCP, which increased our understanding of these phenomena, how ...
Reynald, Danielle M, Leclerc, Benoit
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source