Results 61 to 70 of about 62,613 (263)
Geometric Modeling Using New Cubic Trigonometric B-Spline Functions with Shape Parameter
Mathematics, 2020 Trigonometric B-spline curves with shape parameters are equally important and useful for modeling in Computer-Aided Geometric Design (CAGD) like classical B-spline curves.
Abdul Majeed +5 more
doaj +1 more source
L-systems in Geometric Modeling [PDF]
Electronic Proceedings in Theoretical Computer Science, 2010 We show that parametric context-sensitive L-systems with affine geometry interpretation provide a succinct description of some of the most fundamental algorithms of geometric modeling of curves.
Przemyslaw Prusinkiewicz +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Combined small subgroups and side-channel attack on elliptic curves with cofactor divisible by 2m [PDF]
International Journal of Electronics and Telecommunications, 2019 Nowadays, alternative models of elliptic curves like Montgomery, Edwards, twisted Edwards, Hessian, twisted Hessian, Huff’s curves and many others are very popular and many people use them in cryptosystems which are based on elliptic curve cryptography ...
Michał Wrońska
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Inverse Geometric Reconstruction Based on MW-NURBS Curves
MathematicsCurrently, rational curves such as the Non-Uniform Rational B-Spline (NURBS) play a significant role in both shape representation and shape reconstruction.
Musrrat Ali, Deepika Saini, Sanoj Kumar
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MODULI SPACES OF RATIONAL WEIGHTED STABLE CURVES AND TROPICAL GEOMETRY
Forum of Mathematics, Sigma, 2016 We study moduli spaces of rational weighted stable tropical curves, and their connections with Hassett spaces. Given a vector $w$ of weights, the moduli ...
RENZO CAVALIERI +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source