Results 41 to 50 of about 274,060 (275)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Closed-Form Solutions of a Nonlinear Rational Second-Order Three-Dimensional System of Difference Equations

Mathematics
In this paper, we investigate the behavior of solutions to a nonlinear system of rational difference equations of order two, defined by xn+1=xnyn−1yn(a+bxnyn−1),yn+1=ynzn−1zn(c+dynzn−1),zn+1=znxn−1xn(e+fznxn−1), where n denotes a nonzero integer; the ...
Messaoud Berkal, Taha Radwan, Mehmet Gümüş, Raafat Abo-Zeid, Karim K. Ahmed   +4 more
doaj   +1 more source

Jacobi Elliptic Solutions for Nonlinear Differential Difference Equations in Mathematical Physics

Journal of Applied Mathematics, 2012
We put a direct new method to construct the rational Jacobi elliptic solutions for nonlinear differential difference equations which may be called the rational Jacobi elliptic functions method.
Khaled A. Gepreel, A. R. Shehata
doaj   +1 more source

Linear difference equations, frieze patterns and combinatorial Gale transform [PDF]

, 2013
We study the space of linear difference equations with periodic coefficients and (anti)periodic solutions. We show that this space is isomorphic to the space of tame frieze patterns and closely related to the moduli space of configurations of points in ...
Morier-Genoud, Sophie, Ovsienko, Valentin, Schwartz, Richard Evan, Tabachnikov, Serge   +3 more
core  

Factorizations of Rational Matrix Functions with Application to Discrete Isomonodromic Transformations and Difference Painlev\'e Equations

, 2013
We study factorizations of rational matrix functions with simple poles on the Riemann sphere. For the quadratic case (two poles) we show, using multiplicative representations of such matrix functions, that a good coordinate system on this space is given ...
Anton Dzhamay, Arinkin D Borodin A, Dzhamay A, Krichever I, Krichever I, Krichever I, Soloviev F, Suris Y, Veselov A   +8 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Qualitative Behavior of Bidimensional Rational Fuzzy Difference Equations

Abstract and Applied Analysis
MSC2020 Classification:03E72, 39A10 ...
Najmeddine Attia, Ahmed Ghezal
doaj   +1 more source

On A System of Rational Difference Equation

Demonstratio Mathematica, 2014
Abstract In this paper, we study local asymptotic stability, global character and periodic nature of solutions of the system of rational difference equations given by xn+1= , yn=
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Explicit Solutions and Bifurcations for a System of Rational Difference Equations

Mathematics, 2019
In this paper, we consider the explicit solution of the following system of nonlinear rational difference equations: x n + 1 = x n - 1 / x n - 1 + r , y n + 1 = x n - 1 y n / x n - 1 y n + r , with ...
Bashir Al-Hdaibat, Saleem Al-Ashhab, Ramadan Sabra   +2 more
doaj   +1 more source