Results 51 to 60 of about 1,246,539 (256)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
The International Journal of Banking and Finance, 2009 We shed new light on the relevance of rational expectations and irrational exuberance of U.S. individual and institutional investors on Pacific-Basin stock returns. We find insignificant effects of irrational exuberance and significant effect of rational
Rahul Verma
doaj
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Rational expectations business cycle models: a survey [PDF]
Development of rational expectations models of the business cycle has been the central issue in macroeconomics over the last 15 years. The postulate that expectations are rational imposes considerable discipline on business cycle analysis.
Robert G. King, Michael Dotsey
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Exact controllability of rational expectations model with multiplicative noise and input delay
Journal of Automation and IntelligenceThis paper considers the rational expectations model with multiplicative noise and input delay, where the system dynamics rely on the conditional expectations of future states.
Wenjing Wang +3 more
doaj +1 more source
Modelo de Cagan e quebras estruturais: evidências para o Brasil (1970-94)
Economia Aplicada, 2011 Partindo do modelo proposto por Cagan (1956), analisa-se o comportamento da demanda por moeda e dos preços no Brasil entre 1970 e 1994. São utilizadas técnicas de cointegração robustas à presença de quebras estruturais (determinadas endogenamente), mais ...
Maurício Canêdo-Pinheiro
doaj +1 more source
Policy evaluation and design in the light of rational expectations [PDF]
This thesis examines certain key problems that the existence of forward rational expectations poses for policy analysis. The separate stages of estimating, testing and solving an econometric model are dealt with in turn. The main body of original work is
Snell, Andrew John
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source