Results 51 to 60 of about 226,626 (309)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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Counting rational points on elliptic curves with a rational 2-torsion point [PDF]
Rendiconti Lincei, Matematica e Applicazioni, 2021 Let E/\mathbb{Q} be an elliptic curve over the rational numbers. It is known, by the work of Bombieri and Zannier, that if E has full rational 2-torsion, the number
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
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, 2020 We classify rational, irreducible quartic symmetroids in projective 3-space.
Helsø, Martin
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
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On Rational Distance Point Problem for Quadrilaterals
四川大学学报. 自然科学版, 2016 In the present paper, by pointing out some errors in reference [17], we know that the well-known integer distance point problem of Steinhaus is still open. Using the result of Galois extension, we discuss the Steinhaus problem for some quadrilaterals. In
Yang Shi-Chun, 廖群英
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
On the limits of non-uniform rational B-spline surfaces with varying weights
Advances in Mechanical Engineering, 2017 The non-uniform rational B-spline is a mathematical model commonly used in computer-aided design and manufacturing. For a non-uniform rational B-spline surface, when a single weight approaches infinity, the surface tends to the corresponding control ...
Yue Zhang, Chun-Gang Zhu, Qing-Jie Guo
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Sieving rational points on varieties
Transactions of the American Mathematical Society, 2018 An upper bound sieve for rational points on suitable varieties is developed, together with applications to counting rational points in thin sets, to local solubility in families, and to the notion of “friable” rational points with respect to divisors. In the special case of quadrics, sharper estimates are obtained by developing a version of the Selberg
Browning, Tim, Loughran, Daniel
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
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