Advanced Functional Materials, EarlyView.This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann +2 more
wiley +1 more source
A novel approach to coincidence point results via proximal contractions with application. [PDF]
Sci RepAhmad H, Ishtiaq U, Akram M, Popa IL.
europepmc +1 more source
Advanced Functional Materials, EarlyView.ABSTRACT In this work, we introduce a trifluoromethoxy (OCF3) group as a pseudo‐halogen terminal group design for non‐fullerene acceptors, which combines strong inductive electron‐withdrawing ability with moderate resonance donation. The as‐synthesized BTP‐OCF3, when benchmarked against its methoxy analogue BTP‐OCH3, demonstrates narrowed bandgap ...
Chunliang Li +16 more
wiley +1 more source
Residue-Level Affinity Decomposition via Quantum Electron Density: A Multivariable Framework Applied to HIV-1 Protease Inhibitors. [PDF]
J Phys Chem BGutiérrez-Flores J +7 more
europepmc +1 more source
Adaptive Hydrogels With Spatiotemporal Stiffening Using pH‐Modulating Enzymes
Advanced Functional Materials, EarlyView.The chemomechanical coupling in an adaptive hydrogel is studied to further the development of adaptive hydrogels. This coupling is achieved by embedding a pH‐modulating enzyme in a pH‐responsive hydrogel. The enzymatic reaction can be triggered locally, which generates a pH‐decreasing wave throughout the system, increasing the crosslinking density and ...
Natascha Gray +3 more
wiley +1 more source
Integrating machine learning and physics-based modeling for predictive design of gemcitabine-loaded nanocomposites. [PDF]
Sci RepRahdar A, Fathi-Karkan S, Shirzad M.
europepmc +1 more source
Photon Avalanching Nanoparticles: The Next Generation of Upconverting Nanomaterials?
Advanced Functional Materials, EarlyView.This Perspective outlines the mechanistic foundations that enable photon‐avalanche (PA) behavior in lanthanide nanomaterials and contrasts them with emerging application spaces and forward‐looking design strategies. By bridging threshold engineering, energy‐transfer dynamics, and materials engineering, we provide a coherent roadmap for advancing the ...
Kimoon Lee +7 more
wiley +1 more source
Toward a Mechanistic Framework for Intestinal Drug Permeability: Integrating <i>In Silico</i> Modeling with Biorelevant Assays. [PDF]
ACS OmegaFerreira FJN +2 more
europepmc +1 more source
Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers
Advanced Functional Materials, EarlyView.A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley +1 more source
Smart Nanoparticles Are Not Smart Enough (Yet): A Cell-Aware View of Cancer Nanomedicine. [PDF]
CellsMarchiò S.
europepmc +1 more source