Results 31 to 40 of about 134,696 (267)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
On the zeros and critical points of a rational map
International Journal of Mathematics and Mathematical Sciences, 2001 Let f:ℙ1→ℙ1 be a rational map of degree d. It is well known that f has d zeros and 2d−2 critical points counted with multiplicities. In this note, we explain how those zeros and those critical points are related.
Xavier Buff
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Common Fixed Points of (α,η) − (θ,ϝ) Rational Contractions with Applications
Journal of Mathematics, 2019 We present the notion of set valued (α,η)-(θ,ϝ) rational contraction mappings and then some common fixed point results of such mappings in the setting of metric spaces are established.
Mujahid Abbas +2 more
doaj +1 more source
Mathematics, 2015 The correspondence between right triangles with rational sides, triplets of rational squares in arithmetic succession and integral solutions of certain quadratic forms is well-known.
Erich Selder, Karlheinz Spindler
doaj +1 more source
Noncommutative Rational Double Points
Journal of Algebra, 2000 Let \(k\) be an algebraically closed field of characteristic zero, let \(P=k\langle \langle u,v\rangle \rangle\) be the noncommutative power series ring in the two indeterminates \(u,v\), and \(r\in P\). Suppose that the leading term of \(r\) is quadratic with no linear factors. Then \(B=P/(r)\) is a regular ring of dimension two.
openaire +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Some aspects of rational points and rational curves
, 2023 Various methods have been used to construct rational points and rational curves on rationally connected algebraic varieties. We survey recent advances in two of them, the descent and the fibration method, in a number-theoretical context (rational points over number fields) and in an algebro-geometric one (rational curves on real varieties), and discuss
openaire +3 more sources
Homotopy obstructions to rational points [PDF]
, 2013 In this paper we propose to use a relative variant of the notion of the tale homotopy type of an algebraic variety in order to study the existence of rational points on it. In particular, we use an appropriate notion of homotopy fixed points in order to construct obstructions to the local-global principle.
Harpaz, Yonatan, Schlank, Tomer M.
openaire +3 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source