Results 91 to 100 of about 1,773,167 (249)
Prévention de la défaillance des entreprises
La défaillance représente un évènement spécifique dans la vie de l’entreprise. Il s’agit d’un épisode où celle-ci souffre de dysfonctionnements graves qui compromettent sa continuité et sa survie.
Mohammed HASSAINATE
doaj
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
To investigate whether linear measurements or ratios on the Graf’s “standard plane” ultrasound images of the neonatal/infantile hip, can support the clinically important differentiation between type I and type II hips.
Chlapoutakis Konstantinos +6 more
doaj +1 more source
Una introducción a la investigación webmétrica de empresas [PDF]
La Web ha experimentado un enorme desarrollo en los últimos 20 años. La Webmetría se presenta como una nueva disciplina que pretende estudiar desde un punto de vista cuantitativo este nuevo canal de comunicación mediante la adaptación y aplicación de ...
Romero Frías, Esteban
doaj
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Isokinetic dynamometry is considered the gold standard for assessing muscle strength ratios, whereas tensiomyography (TMG) has emerged as a promising tool for rapid assessment of involuntary muscle contractility.
Daša Weber, Ajda Hrastnik, Alan Kacin
doaj +1 more source

